Evidence map›Paper›PMID 32853334›Full record

ArticleCardiovascular research2021

Mechanism of ventricular premature beats elicited by left stellate ganglion stimulation during acute ischaemia of the anterior left ventricle.

Bastiaan J D Boukens, Michael Dacey, Veronique M F Meijborg, Michiel J Janse, Joseph Hadaya, Peter Hanna, M Amer Swid, Tobias Opthof, Jeffrey L Ardell, Kalyanam Shivkumar and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Bastiaan J D BoukensDepartment of Medical Biology, Amsterdam UMC, University of Amsterdam, Heart Center, Meibergdreef 9, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands.ORCID 0000-0001-6449-145X
Michael DaceyUCLA Cardiac Arrhythmia Center, Los Angeles, CA, USA.ORCID 0000-0003-0514-2246
Veronique M F MeijborgDepartment of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Meibergdreef 9, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands.
Michiel J JanseDepartment of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Meibergdreef 9, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands.
Joseph HadayaUCLA Cardiac Arrhythmia Center, Los Angeles, CA, USA.
Peter HannaUCLA Cardiac Arrhythmia Center, Los Angeles, CA, USA.ORCID 0000-0003-3092-5090
M Amer SwidUCLA Cardiac Arrhythmia Center, Los Angeles, CA, USA.
Tobias OpthofDepartment of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Meibergdreef 9, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands.
Jeffrey L ArdellUCLA Cardiac Arrhythmia Center, Los Angeles, CA, USA.ORCID 0000-0001-9241-0864
Kalyanam ShivkumarUCLA Cardiac Arrhythmia Center, Los Angeles, CA, USA.ORCID 0000-0002-4121-1766
Ruben CoronelDepartment of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Heart Center, Meibergdreef 9, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands.ORCID 0000-0001-9433-6119
Texas Cardiac Arrhythmia · USAmsterdam University Medical Centers · NLUniversité de Bordeaux · FR

Funding

Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4M
Bioelectric monitoring and control of the heartU01EB025138 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDELL, JEFFREY L, KIPKE, DARYL R · 2017 to 2020
$4.0M
Dutch Heart Foundation 2016T047Leducq Foundation 16CVD02NIBIB NIH HHS U01 EB025138NIH HHS OT2 OD023848UCLA Cardiac Arrhythmia Center
6 · The paper itself

Abstract

aimsEnhanced sympathetic activity during acute ischaemia is arrhythmogenic, but the underlying mechanism is unknown. During ischaemia, a diastolic current flows from the ischaemic to the non-ischaemic myocardium. This 'injury' current can cause ventricular premature beats (VPBs) originating in the non-ischaemic myocardium, especially during a deeply negative T wave in the ischaemic zone. We reasoned that shortening of repolarization in myocardium adjacent to ischaemic myocardium increases the 'injury' current and causes earlier deeply negative T waves in the ischaemic zone, and re-excitation of the normal myocardium. We tested this hypothesis by activation and repolarization mapping during stimulation of the left stellate ganglion (LSG) during left anterior descending coronary artery (LAD) occlusion. METHODS AND

resultsIn nine pigs, five subsequent episodes of acute ischaemia, separated by 20 min of reperfusion, were produced by occlusion of the LAD and 121 epicardial local unipolar electrograms were recorded. During the third occlusion, left stellate ganglion stimulation (LSGS) was initiated after 3 min for a 30-s period, causing a shortening of repolarization in the normal myocardium by about 100 ms. This resulted in more negative T waves in the ischaemic zone and more VPBs than during the second, control, occlusion. Following the decentralization of the LSG (including removal of the right stellate ganglion and bilateral cervical vagotomy), fewer VPBs occurred during ischaemia without LSGS. During LSGS, the number of VPBs was similar to that recorded before decentralization.

conclusionLSGS, by virtue of shortening of repolarization in the non-ischaemic myocardium by about 100 ms, causes deeply negative T waves in the ischaemic tissue and VPBs originating from the normal tissue adjacent to the ischaemic border.

Indexed as

Action PotentialsHeart RateAnimalsDisease Models, AnimalElectric StimulationFemaleHeartMyocardial IschemiaStellate GanglionSus scrofaTime FactorsVentricular Premature ComplexesArrhythmiasAutonomic nervous systemInjury currentIschaemiaRepolarization

Identifiers

PMID32853334
PMCPMC8318107
OpenAlexW3081957188

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.