ReviewPLoS neglected tropical diseases2020
Human plague: An old scourge that needs new answers.
Review in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 82 citations in OpenAlex.
- Environmental and Host Blood Interactions ShapePathogens (Basel, Switzerland) · 2026Article
- An adenoviral-vectored vaccine protects mice against aerosol challenge with Yersinia pestis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Evolutionary trends of plague research from 2016 to 2025: A bibliometric analysis.PLoS neglected tropical diseases · 2026Article
- Emergence, global dispersal, and local adaptations ofApplied and environmental microbiology · 2026Review
- Genetic Diversity and Spatial Distribution ofMicroorganisms · 2026Article
- Soil characteristics associated with historical commensal rodent plague foci in Yunnan Province, China.Frontiers in veterinary science · 2026Article
- Influence of natural and anthropogenic drivers on plague risk in Southwest China: A multicenter cross-sectional study.One health (Amsterdam, Netherlands) · 2025Article
- Incorporating Machine Learning Techniques to Enhance Rodent Surveillance in Marginalized Urban Communities.Ecology and evolution · 2025Article
- Plagued by the Past, Pressed by the Present: A One Health Perspective onBiomedicines · 2025Review
- Community-led intensive trapping reduces abundance of key plague reservoir and flea vector.Tropical medicine and health · 2025Article
- Research prioritisation in preparedness for and response to outbreaks of high-consequence pathogens: a scoping review.BMC medicine · 2025Article
- Ecologic, Geoclimatic, and Genomic Factors Modulating Plague Epidemics in Primary Natural Focus, Brazil.Emerging infectious diseases · 2024Article
- A historico-medical perspective on ancient epidemics and their impact on past human societies.Journal of preventive medicine and hygiene · 2024Article
- Review of genotyping methods for Yersinia pestis in Madagascar.PLoS neglected tropical diseases · 2024Review
- Development and evaluation of a multi-target droplet digital PCR assay for highly sensitive and specific detection of Yersinia pestis.PLoS neglected tropical diseases · 2024Article
- Knowledge and practices related to plague persistence in plague-endemic foci, Mbulu District, Tanzania.PLoS neglected tropical diseases · 2024Article
- Flea infestation of rodent and their community structure in frequent and non-frequent plague outbreak areas in Mbulu district, northern Tanzania.International journal for parasitology. Parasites and wildlife · 2024Review
- Socio-ecological risk factors associated with human flea infestations of rural household in plague-endemic areas of Madagascar.PLoS neglected tropical diseases · 2024Article
- Characterization of two affinity matured Anti-Yersinia pestis F1 human antibodies with medical countermeasure potential.PloS one · 2024Article
- Regulatory Functions of PurR inMicroorganisms · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 15 institutions in 7 countries.
Funding
Abstract
Yersinia pestis, the bacterial causative agent of plague, remains an important threat to human health. Plague is a rodent-borne disease that has historically shown an outstanding ability to colonize and persist across different species, habitats, and environments while provoking sporadic cases, outbreaks, and deadly global epidemics among humans. Between September and November 2017, an outbreak of urban pneumonic plague was declared in Madagascar, which refocused the attention of the scientific community on this ancient human scourge. Given recent trends and plague's resilience to control in the wild, its high fatality rate in humans without early treatment, and its capacity to disrupt social and healthcare systems, human plague should be considered as a neglected threat. A workshop was held in Paris in July 2018 to review current knowledge about plague and to identify the scientific research priorities to eradicate plague as a human threat. It was concluded that an urgent commitment is needed to develop and fund a strong research agenda aiming to fill the current knowledge gaps structured around 4 main axes: (i) an improved understanding of the ecological interactions among the reservoir, vector, pathogen, and environment; (ii) human and societal responses; (iii) improved diagnostic tools and case management; and (iv) vaccine development. These axes should be cross-cutting, translational, and focused on delivering context-specific strategies. Results of this research should feed a global control and prevention strategy within a "One Health" approach.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.