Evidence map›Paper›PMID 32853114›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020

Ventilatory heterogeneity in the normal human lung is unchanged by controlled breathing.

G Kim Prisk, Gregory M Petersen, Eric T Geier, Rui C Sá

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. ControlledERJ open research · 2021
    Article
  7. Breathing freely during nitrogen washout.Journal of applied physiology (Bethesda, Md. : 1985) · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

G Kim PriskDepartment of Medicine, University of California, San Diego, California.
Gregory M PetersenDepartment of Medicine, University of California, San Diego, California.
Eric T GeierDepartment of Medicine, University of California, San Diego, California.ORCID 0000-0003-3939-0221
Rui C SáDepartment of Medicine, University of California, San Diego, California.
University of California San Diego · US

Funding

Proton MRI to measure lung ventilation and perfusionR01HL119263 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PRISK, GORDON KIM · 2014 to 2017
$3.6M
Imaging Blood Flow, Ventilation, and Density InteractionsR01HL119201 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.5M
Imaging Hypoxic Pulmonary Vasoconstriction in the Aging Lung with Proton MRIR01HL129990 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.4M
Mapping quantification of ventilation with proton MRI: translation to clinical researchF30HL127980 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GEIER, ERIC T. · 2016 to 2018
$89k
NHLBI NIH HHS F30 HL127980NHLBI NIH HHS HL-119201NHLBI NIH HHS HL-119263NHLBI NIH HHS HL-127980NHLBI NIH HHS HL-129990NHLBI NIH HHS R01 HL119201NHLBI NIH HHS R01 HL119263NHLBI NIH HHS R01 HL129990
6 · The paper itself

Abstract

Measurement of ventilation heterogeneity with the multiple-breath nitrogen washout (MBW) is usually performed using controlled breathing with a fixed tidal volume and breathing frequency. However, it is unclear whether controlled breathing alters the underlying ventilatory heterogeneity. We hypothesized that the width of the specific ventilation distribution (a measure of heterogeneity) would be greater in tests performed during free breathing compared with those performed using controlled breathing. Eight normal subjects (age range = 23-50 yr, 5 female/3 male) twice underwent MRI-based specific ventilation imaging consisting of five repeated cycles with the inspired gas switching between 21% and 100% O

Indexed as

LungRespirationAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRespiratory Function TestsTidal VolumeYoung AdultMBWSVIwashout

Identifiers

PMID32853114
PMCPMC7701356
OpenAlexW3080871256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.