Evidence map›Paper›PMID 32853041›Full record

ArticleVascular medicine (London, England)2020

Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.

Caitlin Parmer, Ana Luisa De Sousa-Coelho, Henry S Cheng, Grace Daher, Alison Burkart, Jonathan M Dreyfuss, Hui Pan, Joshua C Prenner, Jessica M Keilson, Reena Pande and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vascular medicine (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Caitlin ParmerDepartment of Medicine, Stanford University Medical Center, Palo Alto, CA, USA.
Ana Luisa De Sousa-CoelhoCentre for Biomedical Research, Universidade do Algarve, Faro, Portugal.ORCID 0000-0002-8451-4302
Henry S ChengCardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Grace DaherResearch Division, Joslin Diabetes Center, and Harvard Medical School, Boston, MA, USA.
Alison BurkartResearch Division, Joslin Diabetes Center, and Harvard Medical School, Boston, MA, USA.
Jonathan M DreyfussResearch Division, Joslin Diabetes Center, and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7242-3991
Hui PanResearch Division, Joslin Diabetes Center, and Harvard Medical School, Boston, MA, USA.
Joshua C PrennerDepartment of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, USA.
Jessica M KeilsonEmory School of Medicine, Atlanta, GA, USA.
Reena PandeCardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Stanislav HenkinHeart and Vascular Center, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.ORCID 0000-0001-5968-1216
Mark W FeinbergCardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Mary Elizabeth PattiResearch Division, Joslin Diabetes Center, and Harvard Medical School, Boston, MA, USA.
Mark A CreagerHeart and Vascular Center, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.ORCID 0000-0001-9758-6447
Joslin Diabetes Center · USBrigham and Women's Hospital · USDartmouth–Hitchcock Medical Center · USAlgarve Biomedical Center · PTEmory University · USNorthwestern University · USStanford Medicine · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI Alessandro Doria · 1986 to 2026
$50.5M
Clinical Research Training Program for Academic VascularK12HL083786 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CREAGER, MARK A · 2006 to 2011
$4.0M
STARS-SRF Pathway- A Novel Regulator of Muscle Metabolism and Insulin ResistanceR56DK096158 · NIDDK · JOSLIN DIABETES CENTER · PI PATTI, MARY E · 2012 to 2012
$124k
NHLBI NIH HHS K12 HL083786NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R56 DK096158
6 · The paper itself

Abstract

Flow-limiting atherosclerotic lesions of arteries supplying the limbs are a cause of symptoms in patients with peripheral artery disease (PAD). Musculoskeletal metabolic factors also contribute to the pathophysiology of claudication, which is manifest as leg discomfort that impairs walking capacity. Accordingly, we conducted a case-control study to determine whether skeletal muscle metabolic gene expression is altered in PAD. Calf skeletal muscle gene expression of patients with PAD and healthy subjects was analyzed using microarrays. The top-ranking gene differentially expressed between PAD and controls (FDR < 0.001) was

Indexed as

AgedAnimalsCase-Control StudiesDisease Models, AnimalFemaleGene Expression Regulation, EnzymologicHumansInsulin ResistanceIntermittent ClaudicationIschemiaMaleMice, Inbred C57BLMiddle AgedMuscle, SkeletalPeripheral Arterial DiseasePhospholipases A2, Calcium-IndependentPhospholipases A2, Calcium-IndependentPLAAT3 protein, humanPlaat3 protein, mouseTumor Suppressor Proteinsgene expressiongeneticsinsulin resistanceintermittent claudicationperipheral artery disease (PAD)

Identifiers

PMID32853041
PMCPMC12721872
OpenAlexW3080434086

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.