ArticlePediatric pulmonology2020
Digital auscultation in PERCH: Associations with chest radiography and pneumonia mortality in children.
Article in Pediatric pulmonology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07631377 (The LalelaLung Study), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The LalelaLung Study: Digital Stethoscope Clinical Evaluation
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- What are the risk factors for death among children with pneumonia in low- and middle-income countries? A systematic review.Journal of global health · 2023Pooled it
- Wheeze detection in real-world pediatric care: AI applied to smartphone lung auscultation.European journal of pediatrics · 2026Observational
- Digital stethoscope use by non-physician primary care health workers on children under five years of age in rural Bangladesh: a feasibility study.Scientific reports · 2026Article
- Multi-Stage Respiratory Sound Analysis: Confidence-Driven Wheeze and Crackle Detection.IEEE transactions on bio-medical engineering · 2026Article
- Mobile phone auscultation to delineate pneumonia from other respiratory conditions and controls: a prospective cohort study.BMC pulmonary medicine · 2026Article
- Performance of an artificial intelligence algorithm for interpreting lung sounds from children hospitalised with pneumonia in Malawi.Journal of global health · 2025Article
- Diaphragm Design for an Electret Microphone Stethoscope.IEEE sensors journal · 2025Article
- A MEMS seismometer respiratory monitor for work of breathing assessment and adventitious lung sounds detection via deep learning.Scientific reports · 2025Article
- Current Diagnostic Techniques for Pneumonia: A Scoping Review.Sensors (Basel, Switzerland) · 2024Article
- Computer-Aided Lung Auscultation Screening and Radiographic Evaluation of Pediatric Pneumonia.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2024Article
- Clinical algorithm reduces antibiotic use among children presenting with respiratory symptoms to hospital in central Vietnam.Pneumonia (Nathan Qld.) · 2023Article
- Digital Pulmonology Practice with Phonopulmography Leveraging Artificial Intelligence: Future Perspectives Using Dual Microwave Acoustic Sensing and Imaging.Sensors (Basel, Switzerland) · 2023Review
- A machine learning approach to the development and prospective evaluation of a pediatric lung sound classification model.Scientific reports · 2023Article
- Clinical hypoxemia score for outpatient child pneumonia care lacking pulse oximetry in Africa and South Asia.Frontiers in pediatrics · 2023Article
- Digitally recorded and remotely classified lung auscultation compared with conventional stethoscope classifications among children aged 1-59 months enrolled in the Pneumonia Etiology Research for Child Health (PERCH) case-control study.BMJ open respiratory research · 2022Article
- Observational
- Digital auscultation in PERCH: Associations with chest radiography and pneumonia mortality in children.Pediatric pulmonology · 2020Article
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Authors and funding
38 authors at 15 institutions in 10 countries.
Funding
Abstract
backgroundWhether digitally recorded lung sounds are associated with radiographic pneumonia or clinical outcomes among children in low-income and middle-income countries is unknown. We sought to address these knowledge gaps.
methodsWe enrolled 1 to 59monthold children hospitalized with pneumonia at eight African and Asian Pneumonia Etiology Research for Child Health sites in six countries, recorded digital stethoscope lung sounds, obtained chest radiographs, and collected clinical outcomes. Recordings were processed and classified into binary categories positive or negative for adventitial lung sounds. Listening and reading panels classified recordings and radiographs. Recording classification associations with chest radiographs with World Health Organization (WHO)-defined primary endpoint pneumonia (radiographic pneumonia) or mortality were evaluated. We also examined case fatality among risk strata.
resultsAmong children without WHO danger signs, wheezing (without crackles) had a lower adjusted odds ratio (aOR) for radiographic pneumonia (0.35, 95% confidence interval (CI): 0.15, 0.82), compared to children with normal recordings. Neither crackle only (no wheeze) (aOR: 2.13, 95% CI: 0.91, 4.96) or any wheeze (with or without crackle) (aOR: 0.63, 95% CI: 0.34, 1.15) were associated with radiographic pneumonia. Among children with WHO danger signs no lung recording classification was independently associated with radiographic pneumonia, although trends toward greater odds of radiographic pneumonia were observed among children classified with crackle only (no wheeze) or any wheeze (with or without crackle). Among children without WHO danger signs, those with recorded wheezing had a lower case fatality than those without wheezing (3.8% vs. 9.1%, p = .03).
conclusionsAmong lower risk children without WHO danger signs digitally recorded wheezing is associated with a lower odds for radiographic pneumonia and with lower mortality. Although further research is needed, these data indicate that with further development digital auscultation may eventually contribute to child pneumonia care.
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