Evidence map›Paper›PMID 32852864›Full record

ArticleAddiction (Abingdon, England)2021

African Americans now outpace whites in opioid-involved overdose deaths: a comparison of temporal trends from 1999 to 2018.

Debra Furr-Holden, Adam J Milam, Ling Wang, Richard Sadler

Abstract read
PubMed Publisher
In one paragraph

Article in Addiction (Abingdon, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
18.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it, 167 citations in OpenAlex.

  1. Pooled it
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  16. Fair allocation strategies for opioid settlements.Health care management science · 2025
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Debra Furr-HoldenDivision of Public Health, Michigan State University College of Human Medicine, Flint, MI, USA.ORCID 0000-0002-9337-9886
Adam J MilamDivision of Public Health, Michigan State University College of Human Medicine, Flint, MI, USA.ORCID 0000-0001-9306-1598
Ling WangDepartment of Medicine, Michigan State University College of Human Medicine, East Lansing, MI, USA.ORCID 0000-0003-2452-6691
Richard SadlerDivision of Public Health, Michigan State University College of Human Medicine, Flint, MI, USA.ORCID 0000-0002-5130-8561
University of Michigan–Flint · USMichigan State University · US

Funding

The Flint Center for Health Equity SolutionsU54MD011227 · NIMHD · MICHIGAN STATE UNIVERSITY · PI SADLER, RICHARD CASEY · 2016 to 2020
$10.7M
NIMHD NIH HHS U54 MD011227
6 · The paper itself

Abstract

aimsTo estimate racial differences in rates of opioid-involved overdose deaths (OOD) between whites and African Americans in the United States from 1999 to 2018 to (1) identify racial variation in the temporal trends of OOD during the 20-year period and (2) compare trends in OOD rates between whites and African Americans using the Centers for Disease Control and Prevention's (CDC) three defined OOD epidemic periods.

methodsData were obtained from the CDC wide-ranging on-line data for epidemiological research, which combines OOD data from the National Vital Statistics System, and population data from the US Census Bureau. Joinpoint regression models were used to estimate age-adjusted annual percentage change (APC) in OOD by race from 1999 to 2018.

resultsThe temporal trends of OOD varied by race. African Americans had a persistently low rate of OOD and statistically non-significant rate of change in OOD from 1999 to 2012 (APC = 0.47; P > 0.05), with a statistically significant and rapid acceleration in OOD rates in 2012 that persisted to 2018 (APC = 26.16; P < 0.01). Whites had three statistically significant periods of acceleration in OOD rate from 1999 to 2006 (APC = 12.43; P < 0.01), 2006 to 2013 (APC = 4.34, P < 0.01) and the greatest increase from 2013 to 2016 (APC = 18.96; P < 0.01). Whites had a statistically non-significant decrease in OOD from 2016 to 2018 (P = 0.16). The trend for whites more closely aligned with the CDC-defined epidemic periods than for African Americans. During wave 1 (1999-2010), the average annual percentage change (AAPC) for African Americans was significantly lower than for whites (0.47 versus 9.42, P < 0.01); however, by wave 3 (2013-current; defined by the introduction of illicitly manufactured fentanyl), the AAPC was significantly higher in African Americans (26.16 versus 13.19, P < 0.01).

conclusionsDespite historically lower rates of opioid misuse and opioid-involved overdose deaths among African Americans compared with whites, the growth in opioid-involved overdose deaths among African Americans now outpaces that of whites in the United States.

Indexed as

Drug OverdoseOpiate OverdoseAnalgesics, OpioidBlack or African AmericanFentanylHumansUnited StatesWhite PeopleAnalgesics, OpioidFentanylEpidemiologyhealth disparitieshealth equityopioidpolicyrace

Identifiers

PMID32852864
OpenAlexW3080999592

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.