Evidence map›Paper›PMID 32852860›Full record

SynthesisOral diseases2022

Periodontitis in patients with psoriasis: A systematic review and meta-analysis.

Xinze Zhang, Hongqiu Gu, Shang Xie, Yingying Su

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oral diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06897722 (Psoriasis and Periodontitis Are Chronic Inflammatory Diseases Characterized by Immune Dysregulation and Systemic Inflammatory Burden. Both Conditions Share Key Inflammatory Mediators, Including Tumor Necrosis Factor-alpha), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06897722 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Psoriasis and Periodontitis Are Chronic Inflammatory Diseases Characterized by Immune Dysregulation and Systemic Inflammatory Burden. Both Conditions Share Key Inflammatory Mediators, Including Tumor Necrosis Factor-alpha (TNF-α), Interleukin-17A (IL-17A), and YKL-40, Which Contribute to Tissue Destruction and Disease Progression. This Study Aimed to Investigate the Association Between Psoriasis and Periodontal Diseases by Evaluating Clinical Periodontal Parameters and Measuring TNF-α, IL-17A, and YKL-40 Levels in Gingival Crevicular Fluid (GCF) and Serum.

TypeobservationalSponsorZhala Vatankha SainRan2024 to 2025Enrolled100ConditionsPsoriasis (PsO), Periodontal DiseaseArmsTNF-α analysis in GCF, IL-17A analysis in GCF, YKL-40 analysis in GCF, TNF-α analysis in Serum, İL-17A analysis in Serum
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Interplay between Humoral and CLAInternational journal of molecular sciences · 2021
    Trial
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Oral Microbiota Variations in Psoriasis Patients Without Comorbidity.Clinical, cosmetic and investigational dermatology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xinze ZhangDepartment of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hongqiu GuChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shang XieDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
Yingying SuDepartment of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-4532-512X
Capital Medical University · CNPeking University · CN

Funding

National Natural Science Foundation of China 81600829
6 · The paper itself

Abstract

objectiveThe present study aimed to summarize and update the evidence regarding the association between periodontitis and psoriasis.

methodsThe present systematic review was conducted under the guidelines of Transparent Reporting of Systematic Reviews and Meta-Analyses (PRISMA) and was recorded in the PROSPERO database, under registration number CRD42017063799. Three databases (MEDLINE, Embase, and Cochrane Library) were searched up to March 2020. Case-control or cohort studies assessing the association between periodontitis and psoriasis were identified. Quantitative synthesis was conducted with meta-analysis.

resultsA total of 13 studies (11 case-control and two cohort studies) assessing the association between periodontitis and psoriasis were included. Of these 13 articles, 9 showed the prevalence of periodontitis or psoriasis. Therefore, meta-analyses were conducted with data retrieved from the nine studies included. Pooled effect estimate for nine studies showed that patients with periodontitis associated with a higher risk of psoriasis with a pooled OR of 2.87 (95% CI, 1.75-4.69).

conclusionsThis systematic review demonstrated a positive association between periodontitis and psoriasis; however, a causal relationship cannot be established. Due to the weak evidence, caution should be taken when interpreting the results regarding periodontal parameters. Well-designed prospective studies are necessary to evaluate interactions between both diseases.

Indexed as

PeriodontitisPsoriasisCase-Control StudiesCohort StudiesHumansProspective Studiesperiodontitispsoriasissystematic review

Identifiers

PMID32852860
PMCPMC9290533
OpenAlexW3081220345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.