ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2021
Endochondral growth zone pattern and activity in the zebrafish pharyngeal skeleton.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Cell expansion for notochord mechanics and endochondral bone lengthening in zebrafish depends on the 5'-inositol phosphatase Inppl1a.Current biology : CB · 2025Article
- Mitigation of PFOA-Induced Developmental Toxicity inInternational journal of molecular sciences · 2025Article
- A potential role of Fgf3 for epibranchial formation in zebrafish.Frontiers in cell and developmental biology · 2025Article
- The cellular basis of cartilage growth and shape change in larval and metamorphosing Xenopus frogs.PloS one · 2023Article
- Cellular basis of differential endochondral growth in Lake Malawi cichlids.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish.Journal of anatomy · 2022Article
- Review
- Pthlha and mechanical force control early patterning of growth zones in the zebrafish craniofacial skeleton.Development (Cambridge, England) · 2022Article
- Zebrafish endochondral growth zones as they relate to human bone size, shape and disease.Frontiers in endocrinology · 2022Review
- New gene discoveries in skeletal diseases with short stature.Endocrine connections · 2021Review
- Making and shaping endochondral and intramembranous bones.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork").Frontiers in endocrinology · 2021Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEndochondral ossification is a major bone forming mechanism in vertebrates, defects in which can result in skeletal dysplasia or craniofacial anomalies in humans. The zebrafish holds great potential to advance our understanding of endochondral growth zone development and genetics, yet several important aspects of its biology remain unexplored. Here we provide a comprehensive description of endochondral growth zones in the pharyngeal skeleton, including their developmental progression, cellular activity, and adult fates.
resultsPostembryonic growth of the pharyngeal skeleton is supported by endochondral growth zones located either at skeletal epiphyses or synchondroses. Col2a1a and col10a1a in situ hybridization and anti-PCNA immunostaining identify resting-, hypertrophic- and proliferative zones, respectively, in pharyngeal synchondroses. Cellular hypertrophy and matrix deposition contribute little, if at all, to axial growth in most skeletal elements. Zebrafish endochondral growth zones develop during metamorphosis and arrest in adults.
conclusionsTwo endochondral growth zone configurations in the zebrafish pharyngeal skeleton produce either unidirectional (epiphyses) or bidirectional (synchondroses) growth. Cell proliferation drives endochondral growth and its modulation, in contrast to mammalian long bones in which bone length depends more on cell enlargement during hypertrophy and intramembranous ossification is the default mechanism of bone growth in zebrafish adults.
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