ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020
Headache in idiopathic intracranial hypertension. A CGRP-dependent head pain?
Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Long-term headache following cerebral venous thrombosis: a systematic review.The journal of headache and pain · 2026Pooled it
- Cerebrospinal fluid and serum biomarkers in idiopathic intracranial hypertension: A systematic review.Headache · 2025Pooled it
- Surgical Interventions in Idiopathic Intracranial Hypertension-A Comprehensive Multi-Center Study of Outcome and the Role of Treatment Indication.European journal of neurology · 2026Observational
- Intracranial hypertension after MECT: successful transition to rTMS for refractory auditory hallucinations: a case report.Frontiers in psychiatry · 2026Article
- Papilledema is not the point: intracranial pressure dysregulation as a common pathway in migraine and idiopathic intracranial hypertension.Brain communications · 2026Article
- Acute headache treatment in idiopathic intracranial hypertension: treating to the phenotype?The journal of headache and pain · 2025Article
- Migraine-like headache attributed to a causative disorder: primary migraine or secondary headache with a migraine-like phenotype?The journal of headache and pain · 2025Article
- The challenge of diagnosing intracranial pressure elevations as an otolaryngologist.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Review
- Nighttime Primary Headaches in Children: Beyond Hypnic Headache, a Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Calcitonin gene-related peptide in newly diagnosed idiopathic intracranial hypertension: a prospective, cross-sectional, case-control study of cerebrospinal fluid and plasma.The journal of headache and pain · 2025Article
- An interdisciplinary integrated specialized one-stop outpatient clinic for idiopathic intracranial hypertension-a comprehensive assessment of clinical outcome.European journal of neurology · 2024Article
- Therapeutic Cerebral Fluid Puncture in Patients with Idiopathic Intracranial Hypertension: No Short-Term Effect on Neurocognitive Function.Brain sciences · 2024Article
- An interdisciplinary integrated specialized one-stop outpatient clinic for idiopathic intracranial hypertension - a comprehensive assessment of patient satisfaction.The journal of headache and pain · 2024Article
- An interdisciplinary integrated specialized one-stop outpatient clinic for idiopathic intracranial hypertension - an assessment of sick leave, presenteeism, and health care utilization.The journal of headache and pain · 2024Article
- Predictors of disease course and long-term outcomes of idiopathic intracranial hypertension in children and adolescents.European journal of pediatrics · 2023Article
- MRI features of idiopathic intracranial hypertension are not prognostic of visual and headache outcome.The journal of headache and pain · 2023Article
- Treatment with GLP-1 receptor agonists is associated with significant weight loss and favorable headache outcomes in idiopathic intracranial hypertension.The journal of headache and pain · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Headache is the most frequent and often the most severe symptom of idiopathic intracranial hypertension (IIH) clinical presentation, although pain characteristics are very variable among sufferers and the pain may even lack in some cases. Whatever the headache features, refractoriness to treatments, pain worsening in the recumbent position, and frequent awakenings with severe headache late in the night are the specific complains of such patients. However, a migraine or probable migraine headache, mostly with a chronic headache pattern, can be diagnosed in about 2/3 of the cases. In IIH cases without papilledema (IIHWOP), this leads to a high rate of misdiagnosis with primary chronic migraine (CM). Mechanisms responsible for the shared migrainous presentation of CM and IIH/IIHWOP may rely on a pathologic CGRP release from the rich trigemino-vascular innervated dural sinuses, congested in the course of raised intracranial pressure. The possible role of IIHWOP as a powerful and modifiable risk factor for migraine progression is discussed. Further studies investigating the possible efficacy of anti CGRP/receptor antibodies in IIH/IIHWOP headache treatment are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.