ArticleJournal of thrombosis and thrombolysis2021
Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable coronary artery disease: a COMPARE-RACE analysis.
Article in Journal of thrombosis and thrombolysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Enhancing thrombolytic therapy in Japan-dwelling Japanese using clinical ultrasound with microbubble contrast agent.Journal of medical ultrasonics (2001) · 2026Article
- Association between ex vivo thrombogenicity and ischemic outcome in off-pump coronary surgery.Annals of medicine · 2025Article
- Association and Prognostic Implications of "No-Reflow Phenomenon" and Hypercoagulability in Patients With ST-Segment Elevation Myocardial Infarction.JACC. Asia · 2025Article
- Real-world practices of low-molecular-weight heparin for venous thromboembolism prophylaxis in patients hospitalized with COVID-19: a multicenter prospective study from China.Thrombosis journal · 2025Article
- Thromboelastography Reference Values for Third-Trimester Healthy Obstetric Patients in Northern Mexico.Anesthesiology research and practice · 2025Article
- Comparative studies between humans and golden Syrian hamsters via thromboelastography.Animal models and experimental medicine · 2024Article
- Ethnic Differences in Thrombotic Profiles of Acute Coronary Syndrome Patients and Relationship to Cardiovascular Outcomes: A Comparison of East Asian and White subjects.Thrombosis and haemostasis · 2024Article
- Asian race is not associated with increased 30-day serious complications or mortality: a MBSAQIP analysis of 594,837 patients.Surgical endoscopy · 2023Article
- Thromboembolic events in hospitalised patients with COVID-19: ecological assessment with a scoping review.BMJ open · 2023Article
- Thrombosis and Anticoagulation in East Asian Patients With COVID-19: Another Phenotype of "East Asian Paradox".JACC. Asia · 2022Article
- Is Endogenous Fibrinolysis a Major Player in Occurrence of Atherothrombotic Events Following Acute Myocardial Infarction?JACC. Basic to translational science · 2022Article
- An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke.Thrombosis and haemostasis · 2022Article
- Reduction or de-escalation of dual antiplatelet therapy intensity or duration in patients with acute coronary syndromes undergoing percutaneous coronary intervention: A mini-review.Frontiers in cardiovascular medicine · 2022Review
- Effects of Monotherapy with Clopidogrel vs. Aspirin on Vascular Function and Hemostatic Measurements in Patients with Coronary Artery Disease: The Prospective, Crossover I-LOVE-MONO Trial.Journal of clinical medicine · 2021Article
- Ethnic Difference of Thrombogenicity in Patients with Cardiovascular Disease: a Pandora Box to Explain Prognostic Differences.Korean circulation journal · 2021Review
- Race-Related disparities in COVID-19 thrombotic outcomes: Beyond social and economic explanations.EClinicalMedicine · 2020Article
- Another Unmet Need against Residual Risk of Atherosclerotic Cardiovascular Disease: Can "Thrombin Pathway" Be a New Target for Therapy?Korean circulation journal · 2020Article
- Association Between Thrombogenicity Indices and Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction.JACC. Basic to translational scienceArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compared with Caucasian patients, East Asian patients with coronary artery disease (CAD) have demonstrated better clinical outcomes. We sought to compare the viscoelastic properties of clot formation and their impact on clinical outcomes in East Asian vs. Caucasian patients. We analyzed age- and sex-matched East Asian and Caucasian patients with stable CAD (n = 249 each). Viscoelastic properties of clot formation were assessed with thromboelastography (TEG), and 3-year clinical outcomes were recorded. Major adverse cardiovascular events (MACE) were defined as a composite of cardiovascular death, myocardial infarction, or stroke. Compared with Caucasians, East Asians showed lower platelet-fibrin clot strength (PFCS) (maximum amplitude [MA]: 61.8 ± 7.9 vs. 65.4 ± 5.0 mm, p < 0.001). In a multivariate analysis, high PFCS (defined as MA ≥ 68 mm) was significantly associated with MACE occurrence (odds ratio 6.27, 95% CI 2.41 to 16.30, p < 0.001). East Asians vs. Caucasians had lower prevalence of high PFCS (odds ratio 0.50, 95% CI 0.27 to 0.93, p = 0.028). In conclusion, this is the first study to demonstrate different viscoelastic properties of clot between East Asian and Caucasian patients with stable CAD. The platelet-fibrin clot strength was significantly associated with MACE in these patients and was significantly lower in East Asians. Future studies are warranted to further explore the mechanistic explanation and clinical importance of these findings.
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