Evidence map›Paper›PMID 32852663›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2020

Autonomic symptoms, cardiovascular and sudomotor evaluation in de novo type 1 narcolepsy.

Camilla Rocchi, Fabio Placidi, Chiara Del Bianco, Claudio Liguori, Antonio Pisani, Nicola B Mercuri, Francesca Izzi

Abstract read
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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. When a trail leads to a highway: enhancing the understanding of hypertension in pediatric type 1 narcolepsy.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Autonomic nervous system dysfunction in narcolepsy type 1: time to move forward to the next level?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Camilla RocchiNeurology Unit, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Fabio PlacidiSleep Medicine Center, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
Chiara Del BiancoSleep Medicine Center, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
Claudio LiguoriSleep Medicine Center, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
Antonio PisaniSleep Medicine Center, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy.
Nicola B MercuriNeurology Unit, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Rome, Italy.
Francesca IzziSleep Medicine Center, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome "Tor Vergata", Viale Oxford 81, 00133, Rome, Italy. fraizzi@tin.it.ORCID http://orcid.org/0000-0003-2490-8761
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate cardiovascular and sudomotor function during wakefulness and to assess autonomic symptoms in de novo patients with type 1 narcolepsy compared to healthy controls.

methodsDe novo patients with type 1 narcolepsy (NT1) and healthy controls underwent cardiovascular function tests including head-up tilt test, Valsalva maneuver, deep breathing, hand grip, and cold face, and sudomotor function was assessed through Sudoscan. Autonomic symptoms were investigated using the Scales for Outcomes in Parkinson's Disease-Autonomic Dysfunction (SCOPA-AUT) questionnaire.

resultsTwelve de novo patients with NT1 and 14 healthy controls were included. In supine rest condition and at 3 min and 10 min head-up tilt test, the systolic blood pressure values were significantly higher in the NT1 group than in controls (p < 0.05). A lower Valsalva ratio (p < 0.01), significantly smaller inspiratory-expiratory difference in deep breathing (p < 0.05), and lower delta heart rate in the cold face test (p < 0.01) were also observed in the NT1 group. The mean hand electrochemical skin conductance values were significantly lower (p < 0.05) and the mean SCOPA-AUT total scores were significantly higher in patients with NT1 than in healthy subjects (p < 0.001), with greater involvement of cardiovascular and thermoregulatory items.

conclusionDe novo patients with NT1 exhibit blunted parasympathetic activity during wakefulness, mild sudomotor dysfunction, and a large variety of autonomic symptoms.

Indexed as

Autonomic Nervous System DiseasesCardiovascular SystemNarcolepsyHand StrengthHeart RateHumansTilt-Table TestAutonomic nervous system (ANS)Cardiovascular reflexesNarcolepsy type 1 (NT1)Scales for Outcomes in Parkinson’s Disease–Autonomic Dysfunction questionnaire (SCOPA-AUT)Sudomotor function

Identifiers

PMID32852663
OpenAlexW3081180677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.