Evidence map›Paper›PMID 32852661›Full record

ReviewHeart failure reviews2021

Cardiac contractility modulation for the treatment of heart failure with reduced ejection fraction.

Peysh A Patel, Ramesh Nadarajah, Noman Ali, John Gierula, Klaus K Witte

Abstract readReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Peysh A PatelDepartment of Cardiology, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. peyshpatel@nhs.net.
Ramesh NadarajahDepartment of Cardiology, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK.
Noman AliDepartment of Cardiology, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK.
John GierulaDepartment of Cardiology, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK.
Klaus K WitteDepartment of Cardiology, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK.
Leeds General Infirmary · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been a progressive evolution in the management of patients with chronic heart failure and reduced ejection fraction (HFrEF), including cardiac resynchronisation therapy (CRT) in those that fulfil pre-defined criteria. However, there exists a significant proportion with refractory symptoms in whom CRT devices are not clinically indicated or ineffective. Cardiac contractility modulation (CCM) is a novel therapy that incorporates administration of non-excitatory electrical impulses to the interventricular septum during the absolute refractory period. Implantation is analogous to a traditional transvenous pacemaker system, but with the use of two right ventricular leads. Mechanistic studies have shown augmentation of left ventricular contractility and beneficial global effects on reverse remodeling, primarily through alterations in calcium handling. This appears to occur without increasing myocardial oxygen consumption. Data from clinical trials have shown translational improvements in functional capacity and quality of life, though long-term outcome data are lacking. This review explores the rationale, evidence base and limitations of this nascent technology.

Indexed as

Heart FailureVentricular Dysfunction, LeftHumansMyocardial ContractionQuality of LifeStroke VolumeTreatment OutcomeCCMCHFHeart failureLVSD

Identifiers

PMID32852661
OpenAlexW3080245480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.