Evidence map›Paper›PMID 32851926›Full record

ArticleTechnology in cancer research & treatment

Clinical Value of Serum and Exhaled Breath Condensate miR-186 and IL-1β Levels in Non-Small Cell Lung Cancer.

Haiqin Xie, Jinliang Chen, Xuedong Lv, Lu Zhang, Jinnan Wu, Xin Ge, Qichang Yang, Dongmei Zhang, Jianrong Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Haiqin XieDepartment of Respiratory Medicine, Affiliated Hospital 2 of Nantong University, Nantong, China.ORCID 0000-0002-9109-1299
Jinliang ChenDepartment of Respiratory Medicine, Affiliated Hospital 2 of Nantong University, Nantong, China.
Xuedong LvDepartment of Respiratory Medicine, Affiliated Hospital 2 of Nantong University, Nantong, China.
Lu ZhangDepartment of Respiratory Medicine, Affiliated Hospital 2 of Nantong University, Nantong, China.
Jinnan WuDepartment of Respiratory Medicine, Affiliated Hospital 2 of Nantong University, Nantong, China.
Xin GeMedical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, China.
Qichang YangDepartment of Pathology, Affiliated Hospital 2 of Nantong University, Nantong, China.
Dongmei ZhangMedical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, China.
Jianrong ChenDepartment of Respiratory Medicine, Affiliated Hospital 2 of Nantong University, Nantong, China.
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOur study aimed to investigate the expression level and clinical significance of serum and exhaled breath condensate miR-186 and IL-1β in non-small cell lung cancer patients.

methodsThe serum and exhaled breath condensate specimens of 62 non-small cell lung cancer patients and 60 healthy controls were collected to detect miR-186 expression levels by real-time fluorescent quantitative PCR. Enzyme linked immunosorbent assay was applied to examine IL-1β concentration. Statistical analyses were used to evaluate the correlation between miR-186 and IL-1β in serum and clinicopathological features, traditional serum tumor markers, and inflammatory markers. The diagnostic efficacy of miR-186 and IL-1β for non-small cell lung cancer was evaluated by receiver operating characteristic curve analysis. The correlation between miR-186 and IL-1β was determined.

results① The relative expression level of miR-186 was greatly reduced in the serum and EBC of patients with non-small cell lung cancer, and the miR-186 expression level was reduced in different TNM stages of non-small cell lung cancer, from the early to later stages. ② The IL-1β concentration in serum and exhaled breath condensate of patients with non-small cell lung cancer was increased. ③ Serum miR-186 and IL-1β levels were closely related to lymph node metastasis, and the low expression of serum miR-186 and the high concentration of IL-1β were associated with higher serum carcinoembryonic antigen, C-reactive protein, and erythrocyte sedimentation rate levels. ④ ROC curve analysis showed that exhaled breath condensate miR-186 had higher area under the curve than serum miR-186, and the combined detection showed higher diagnostic efficacy than the separate detection. In addition, the combined detection of IL-1β and miR-186 has a larger AUC than the separate detection of both. ⑤ The correlation between serum miR-186 and IL-1β was negative.

conclusionmiR-186 and IL-1β are expected to be potential diagnostic biomarkers for non-small cell lung cancer.

Indexed as

Circulating MicroRNAAdultAgedBiomarkers, TumorCarcinoma, Non-Small-Cell LungCase-Control StudiesCytokinesExhalationFemaleHumansInflammation MediatorsInterleukin-1betaLung NeoplasmsMaleMicroRNAsMiddle AgedBiomarkers, TumorCirculating MicroRNACytokinesIL1B protein, humanInflammation MediatorsInterleukin-1betaMicroRNAsMIRN186 microRNA, humandiagnosisexhaled breath condensateinterleukin-1βmiR-186non-small cell lung cancer

Identifiers

PMID32851926
PMCPMC7457640
OpenAlexW3081063396

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.