Evidence map›Paper›PMID 32851730›Full record

ArticleExperimental physiology2020

Oestradiol affects skeletal muscle mass, strength and satellite cells following repeated injuries.

Alexie A Larson, Cory W Baumann, Michael Kyba, Dawn A Lowe

Open access · greenAbstract read
In one paragraph

Article in Experimental physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Metabolic Messengers: oestradiol.Nature metabolism · 2025
    Review
  11. Article
  12. Traumatic Skeletal Muscle Injury and Recovery.Advances in experimental medicine and biology · 2025
    Review
  13. Sexual dimorphisms in skeletal muscle: current concepts and research horizons.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Skeletal muscle wasting: the estrogen side of sexual dimorphism.American journal of physiology. Cell physiology · 2022
    Review
  19. Article
  20. Sex Hormones and Satellite Cell Regulation in Women.Translational sports medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexie A LarsonDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0003-0807-1172
Cory W BaumannDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-2457-1911
Michael KybaLillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-5579-7534
Dawn A LoweDivisions of Rehabilitation Science and Physical Therapy, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-5784-9289
University of Minnesota Medical Center · USUniversity of Minnesota · US

Funding

TRAINING PROGRAM IN MUSCLE RESEARCHT32AR007612 · NIAMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JAMES M ERVASTI, DAWN A LOWE · 2001 to 2026
$11.3M
Interatction of Estrogen, Age and Activity on Musculoskeletal Strength in FemalesR01AG031743 · NIA · UNIVERSITY OF MINNESOTA · PI DAWN A LOWE · 2009 to 2026
$7.4M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
Dissecting Effects of Estrogen Deficiency on Satellite Cells and Muscle Regeneration in Females and MalesR01AG062899 · NIA · UNIVERSITY OF MINNESOTA · PI KYBA, MICHAEL, LOWE, DAWN A · 2019 to 2023
$2.5M
NIAMS NIH HHS T32 AR007612NIA NIH HHS R01 AG031743NIA NIH HHS R01 AG062899NIA NIH HHS T32 AG029796
6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? Oestradiol (E ABSTRACT: Oestradiol's effects on skeletal muscle are multifactorial including the preservation of mass, contractility and regeneration. Here, we aimed to determine the extent to which oestradiol deficiency affects strength recovery when muscle is challenged by multiple BaCl

Indexed as

AnimalsEstradiolFemaleLongitudinal StudiesMiceMice, Inbred C57BLMuscle, SkeletalMuscle StrengthMuscular DiseasesOvariectomyReinjuriesSatellite Cells, Skeletal MuscleTorqueEstradiolmuscle stem cellsoestrogenovariectomyrecoveryskeletal muscle

Identifiers

PMID32851730
PMCPMC7722039
OpenAlexW3080616017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.