Evidence map›Paper›PMID 32851648›Full record

ArticleAnaesthesia2021

Screening and treating pre-operative anaemia and suboptimal iron stores in elective colorectal surgery: a cost effectiveness analysis.

K M Trentino, H S Mace, K Symons, F M Sanfilippo, M F Leahy, S L Farmer, A Hofmann, R D Watts, M H Wallace, K Murray

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Article
  7. Which should be the target for preoperative hemoglobin optimization?Blood transfusion = Trasfusione del sangue · 2025
    Article
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  10. SucrosomialPharmaceuticals (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

K M TrentinoMedical School, University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-8768-9263
H S MaceDepartment of Anaesthesia and Pain Medicine, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
K SymonsDepartment of Anaesthesia and Pain Medicine, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
F M SanfilippoSchool of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.
M F LeahyDepartment of Haematology, PathWest Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia.
S L FarmerMedical School, University of Western Australia, Perth, Western Australia, Australia.
A HofmannSchool of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.
R D WattsSchool of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.
M H WallaceSchool of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.
K MurraySchool of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.

Funding

AmgenCelgeneNational Blood AuthoritySouth African National Blood ServiceTakedaTEM InnovationsThiemeVifor Pharma International AG
6 · The paper itself

Abstract

Our study investigated whether pre-operative screening and treatment for anaemia and suboptimal iron stores in a patient blood management clinic is cost effective. We used outcome data from a retrospective cohort study comparing colorectal surgery patients admitted pre- and post-implementation of a pre-operative screening programme. We applied propensity score weighting techniques with multivariable regression models to adjust for differences in baseline characteristics between groups. Episode-level hospitalisation costs were sourced from the health service clinical costing data system; the economic evaluation was conducted from a Western Australia Health System perspective. The primary outcome measure was the incremental cost per unit of red cell transfusion avoided. We compared 441 patients screened in the pre-operative anaemia programme with 239 patients not screened; of the patients screened, 180 (40.8%) received intravenous iron for anaemia and suboptimal iron stores. The estimated mean cost of screening and treating pre-operative anaemia was AU$332 (£183; US$231; €204) per screened patient. In the propensity score weighted analysis, screened patients were transfused 52% less red cell units when compared with those not screened (rate ratio = 0.48, 95%CI 0.36-0.63, p < 0.001). The mean difference in total screening, treatment and hospitalisation cost between groups was AU$3776 lower in the group screened (£2080; US$2629; €2325) (95%CI AU$1604-5947, p < 0.001). Screening elective patients pre-operatively for anaemia and suboptimal iron stores reduced the number of red cell units transfused. It also resulted in lower total costs than not screening patients, thus demonstrating cost effectiveness.

Indexed as

AnemiaCohort StudiesColorectal SurgeryCost-Benefit AnalysisElective Surgical ProceduresErythrocyte TransfusionFemaleHealth Care CostsHumansIronMaleMiddle AgedPreoperative CareRetrospective StudiesWestern AustraliaIronanaemiacost effectivenessiron deficiencypre-operative screening

Identifiers

PMID32851648
PMCPMC7891607

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.