Evidence map›Paper›PMID 32851638›Full record

ArticleThe Journal of physiology2020

Regulation of chemoconvulsant-induced seizures by store-operated Orai1 channels.

Kotaro Hori, Shogo Tsujikawa, Michaela M Novakovic, Megumi Yamashita, Murali Prakriya

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Congenital tubular aggregates myopathy associated with central nervous system involvement: description of a case.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2024
    Article
  6. Review
  7. SOCE as a regulator of neuronal activity.The Journal of physiology · 2024
    Review
  8. Article
  9. Mitochondrial calcium cycling in neuronal function and neurodegeneration.Frontiers in cell and developmental biology · 2023
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kotaro HoriDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Shogo TsujikawaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Michaela M NovakovicDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Megumi YamashitaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Murali PrakriyaDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-0781-4480
Northwestern University · US

Funding

PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIAT32AG020506 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR, SANDRA WEINTRAUB · 2002 to 2026
$9.9M
Store-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4M
Regulation of synaptic plasticity and cognitive functions by store-operated Orai1 channelsR01NS115508 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2020 to 2022
$1.3M
NIA NIH HHS T32 AG020506NINDS NIH HHS R01 NS057499NINDS NIH HHS R01 NS115508
6 · The paper itself

Abstract

key pointsTemporal lobe epilepsy is a complex neurological disease caused by imbalance of excitation and inhibition in the brain. Growing literature implicates altered Ca ABSTRACT: Store-operated Orai1 channels are a major mechanism for Ca

Indexed as

HippocampusSeizuresAnimalsKainic AcidMiceORAI1 ProteinPilocarpinePyramidal CellsKainic AcidORAI1 ProteinOrai1 protein, mousePilocarpineCRAC channelhippocampuskainic acidOrai1pilocarpineseizuresSTIM1

Identifiers

PMID32851638
PMCPMC7896430
OpenAlexW3080845928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.