Evidence map›Paper›PMID 32851575›Full record

ArticleInternational urology and nephrology2020

Decreased insulin-like growth factor-1 (IGF-1) concentration correlates with reduced left-ventricle ejection fraction (LVEF) in hemodialysis patients.

Vladimir Prelevic, Tanja Antunovic, Danilo Radunovic, Najdana Gligorovic Barhanovic, Branka Gledovic, Nebojsa Bulatovic, Marina Ratkovic, Nikolina Basic-Jukic

Abstract readMulticenter Study
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In one paragraph

Article in International urology and nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vladimir PrelevicClinic for Nephrology, Clinical Center of Montenegro, Ljubljanska bb, 81000, Podgorica, Montenegro. vladimir.scopheurope@gmail.com.
Tanja AntunovicCenter for Clinical-Laboratory Diagnostics, Clinical Centre of Montenegro, Ljubljanska bb, Podgorica, 81000, Montenegro.
Danilo RadunovicClinic for Nephrology, Clinical Center of Montenegro, Ljubljanska bb, 81000, Podgorica, Montenegro.
Najdana Gligorovic BarhanovicCenter for Clinical-Laboratory Diagnostics, Clinical Centre of Montenegro, Ljubljanska bb, Podgorica, 81000, Montenegro.
Branka GledovicClinic for Nephrology, Clinical Center of Montenegro, Ljubljanska bb, 81000, Podgorica, Montenegro.
Nebojsa BulatovicClinic for Heart Disease, Clinical Centre of Montenegro, Ljubljanska bb, Podgorica, 81000, Montenegro.
Marina RatkovicClinic for Nephrology, Clinical Center of Montenegro, Ljubljanska bb, 81000, Podgorica, Montenegro.
Nikolina Basic-JukicDepartment of Nephrology, Arterial Hypertension, Dialysis and Kidney Transplantation, Clinic for Internal Medicine, University Clinical Hospital Centre Zagreb, Kispaticeva 12, Zagreb, 10000, Croatia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe main purpose of this study is to determine the correlation between the serum IGF-1 concentration and certain cardiac indexes in hemodialysis patients.

methodsThe study was conducted at the Clinical Center of Montenegro and three regional hemodialysis centers. The echocardiographic studies were performed the day after the hemodialysis sessions. Blood samples were taken before dialysis for the measurement of IGF1 and PTH.

resultsA total of 102 patients were divided into two groups according to their left-ventricular ejection fraction (EF). Patients in the group with the higher EF had higher IGF-1 concentration (p = 0.024). IGF-1 was positively correlated with EF (ρ = 0.251, p = 0.012), and negatively correlated with LVMI (ρ = - 0.621, p < 0.001), SW (ρ = - 0.632, p < 0.001), and LW (ρ = - 0.632, p < 0.001). Multiple linear regression analysis was performed to determine the possible independent association between the EF and IGF-1 and the clinical data. The age of patients, their gender, and smoking habits did not have any combined influence on EF, but IGF-1 had a strong influence and was independently associated with the ejection fraction.

conclusionOur results may indicate the possible protective role of IGF-1 in the maintenance of heart structure and function in hemodialysis patients.

Indexed as

Renal DialysisStroke VolumeVentricular Function, LeftAgedCohort StudiesCorrelation of DataFemaleHumansInsulin-Like Growth Factor IMaleMiddle AgedInsulin-Like Growth Factor ICardiovascularHemodialysisIGF1Outcome

Identifiers

PMID32851575

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