Evidence map›Paper›PMID 32851522›Full record

ArticleEnvironmental science and pollution research international2021

Antitumor effect of copper nanoparticles on human breast and colon malignancies.

Mohammed Al-Zharani, Ashraf Ahmed Qurtam, Walid Mohamed Daoush, Mohamed Hassan Eisa, Nada Hamad Aljarba, Saad Alkahtani, Fahd A Nasr

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In one paragraph

Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Mohammed Al-ZharaniBiology Department, College of Science, Imam Mohammad ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia. MMyLzahrani@Imamu.edu.sa.
Ashraf Ahmed QurtamBiology Department, College of Science, Imam Mohammad ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.
Walid Mohamed DaoushChemistry Department, College of Science, Imam Mohammad ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.
Mohamed Hassan EisaPhysics Department, College of Science, Imam Mohammad ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.
Nada Hamad AljarbaBiology Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Saad AlkahtaniDepartment of Zoology, Science College, King Saud University, Riyadh, Saudi Arabia.
Fahd A NasrMedicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Imam Mohammad ibn Saud Islamic University · SAKing Saud University · SAPrincess Nourah bint Abdulrahman University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast and colon carcinomas are two types of common cancers which lead to cancer-related deaths. Due to their cytotoxic potential against cancer cells, recently many studies of copper nanoparticles (CuNPs) have been conducted. In the current work, we aim to evaluate the cytotoxic and apoptosis-inducing effects of CuNPs on the human breast (MCF-7) and colon (LoVo) cancer cells. CuNPs were prepared in starch-stabilizing aqueous solution by electroless deposition technique in alkaline tartrate bath using formaldehyde as the reducing agent of copper sulfate. The obtained CuNPs were characterized by SEM, TEM, and XRD to confirm the particle size, morphology, and chemical composition. Standard colorimetric MTT and LDH assays were used to estimate the cytotoxic effect of CuNPs on MCF-7 and LoVo cells. Furthermore, CuNP-treated cells undergoing apoptosis were assessed based on the expression of apoptosis-related genes using qRT-PCR. The results indicate that the mean particle size of the synthesized CuNPs was ~ 50-60 nm, and they were spherical in shape with mainly the chemical structure of the copper metallic phase. MTT assay revealed that CuNPs induced cytotoxicity in tested cells with IC

Indexed as

Breast NeoplasmsColonic NeoplasmsMetal NanoparticlesNanoparticlesCopperHumansParticle SizeCopperAnti-cancer activityBreast cancerChemical reduction apoptosisColon cancerCopper nanoparticles

Identifiers

PMID32851522
OpenAlexW3080505698

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.