ArticleInternational journal of epidemiology2020
Mismatch between poor fetal growth and rapid postnatal weight gain in the first 2 years of life is associated with higher blood pressure and insulin resistance without increased adiposity in childhood: the GUSTO cohort study.
Article in International journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07349966 (A Prospective Observational Study of the Impact of Blastocyst Biopsy on Postnatal Growth in Children Born After Preimplantation Genetic Testing), which is not on this map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Observational Study of the Impact of Blastocyst Biopsy on Postnatal Growth in Children Born After Preimplantation Genetic Testing
Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children's Study.BMC medicine · 2026Article
- Risk Factors for Rapid Growth in Undernourished Children: Analysis of Indonesian Family Life Survey.Acta medica Philippina · 2026Article
- Using human genetics to understand the epidemiological association between child obesity at different ages and MASLD.International journal of surgery (London, England) · 2026Article
- Weight gain in infancy and metabolic dysfunction-associated steatotic liver disease (MASLD) in a prospective birth cohort of Latino children.Maternal health, neonatology and perinatology · 2025Article
- Early milk cereal drink consumption correlated with rapid weight gain but not with subsequent adiposity.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- The Impact of Rapid Growth After Retardation at the First 1000 Days of Life (FDLs) on the Risk of Noncommunicable Diseases in Indonesian Adolescence.International journal of pediatrics · 2025Article
- Evolving global trends in PCOS burden: a three-decade analysis (1990-2021) with projections to 2036 among adolescents and young adults.Frontiers in endocrinology · 2025Article
- Associations of fetal and postnatal growth trajectories with child cognition: the GUSTO cohort study.International journal of epidemiology · 2024Article
- Gaps in the usage and reporting of multiple imputation for incomplete data: findings from a scoping review of observational studies addressing causal questions.BMC medical research methodology · 2024Article
- Fetal femur length and risk of diabetes in adolescence: a prospective cohort study.Tropical medicine and health · 2024Article
- SPISE INDEX (Single point insulin sensitivity estimator): indicator of insulin resistance in children and adolescents with overweight and obesity.Frontiers in endocrinology · 2024Article
- Cleavage-stage or blastocyst-stage embryo biopsy has no impact on growth and health in children up to 2 years of age.Reproductive biology and endocrinology : RB&E · 2023Article
- Myo-inositol alters the effects of glucose, leptin and insulin on placental palmitic acid and oleic acid metabolism.The Journal of physiology · 2023Article
- Fetal Growth Trajectories and Measures of Insulin Resistance in Young Adults.The Journal of clinical endocrinology and metabolism · 2023Article
- Long-term implications of fetal growth restriction.World journal of clinical cases · 2023Review
- Article
- Pregnancies complicated by gestational diabetes and fetal growth restriction: an analysis of maternal and fetal body composition using magnetic resonance imaging.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study.The lancet. Diabetes & endocrinology · 2022Observational
- Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placentalScientific reports · 2022Article
- The single-point insulin sensitivity estimator (SPISE) index is a strong predictor of abnormal glucose metabolism in overweight/obese children: a long-term follow-up study.Journal of endocrinological investigation · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
27 authors at 6 institutions in 5 countries.
Funding
Abstract
backgroundUsing longitudinal ultrasounds as an improved fetal growth marker, we aimed to investigate if fetal growth deceleration followed by rapid postnatal weight gain is associated with childhood cardiometabolic risk biomarkers in a contemporary well-nourished population.
methodsWe defined fetal growth deceleration (FGD) as ultrasound-measured 2nd-3rd-trimester abdominal circumference decrease by ≥0.67 standard deviation score (SDS) and rapid postnatal weight gain (RPWG) as 0-2-year-old weight increase by ≥0.67 SDS. In the GUSTO mother-offspring cohort, we grouped 797 children into four groups of FGD-only (14.2%), RPWG-only (23.3%), both (mismatch, 10.7%) or neither (reference, 51.8%). Adjusting for confounders and comparing with the reference group, we tested associations of these growth groups with childhood cardiometabolic biomarkers: magnetic resonance imaging (MRI)-measured abdominal fat (n = 262), liver fat (n = 216), intramyocellular lipids (n = 227), quantitative magnetic resonance-measured overall body fat % (BF%) (n = 310), homeostasis model assessment of insulin resistance (HOMA-IR) (n = 323), arterial wall thickness (n = 422) and stiffness (n = 443), and blood pressure trajectories (ages 3-6 years).
resultsMean±SD birthweights were: FGD-only (3.11 ± 0.38 kg), RPWG-only (3.03 ± 0.37 kg), mismatch (2.87 ± 0.31 kg), reference (3.30 ± 0.36 kg). FGD-only children had elevated blood pressure trajectories without correspondingly increased BF%. RPWG-only children had altered body fat partitioning, higher BF% [BF = 4.26%, 95% confidence interval (CI) (2.34, 6.19)], HOMA-IR 0.28 units (0.11, 0.45)] and elevated blood pressure trajectories. Mismatch children did not have increased adiposity, but had elevated ectopic fat, elevated HOMA-IR [0.29 units (0.04,0.55)] and the highest blood pressure trajectories. Associations remained even after excluding small-for-gestational-age infants from analyses.
conclusionsFetal growth deceleration coupled with rapid postnatal weight gain was associated with elevated childhood cardiometabolic risk biomarkers without correspondingly increased BF%.
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