ArticleBrain : a journal of neurology2020
Hippocampus co-atrophy pattern in dementia deviates from covariance patterns across the lifespan.
Article in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer's disease, Down syndrome, and Parkinson's disease.NPJ dementia · 2026Article
- Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer's disease pathology.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identifying modifiable factors associated with neuroimaging markers of brain health.CNS neuroscience & therapeutics · 2024Article
- Review
- Morphological connectivity differences in Alzheimer's disease correlate with gene transcription and cell-type.Human brain mapping · 2023Article
- Mapping the macrostructure and microstructure of the in vivo human hippocampus using diffusion MRI.Human brain mapping · 2023Article
- A neuroimaging biomarker for Individual Brain-Related Abnormalities In Neurodegeneration (IBRAIN): a cross-sectional study.EClinicalMedicine · 2023Article
- Hippocampal metabolic subregions and networks: Behavioral, molecular, and pathological aging profiles.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Hippocampal anterior- posterior shift in childhood and adolescence.Progress in neurobiology · 2023Article
- Functional activity level reported by an informant is an early predictor of Alzheimer's disease.BMC geriatrics · 2023Article
- Structural covariance network of the hippocampus-amygdala complex in medication-naïve patients with first-episode major depressive disorder.Psychoradiology · 2022Article
- Medial Temporal Lobe Networks in Alzheimer's Disease: Structural and Molecular Vulnerabilities.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Individual prediction and classification of cognitive impairment in patients with white matter lesions based on gray matter volume.Annals of translational medicine · 2022Article
- The many dimensions of human hippocampal organization and (dys)function.Trends in neurosciences · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The hippocampus is a plastic region and highly susceptible to ageing and dementia. Previous studies explicitly imposed a priori models of hippocampus when investigating ageing and dementia-specific atrophy but led to inconsistent results. Consequently, the basic question of whether macrostructural changes follow a cytoarchitectonic or functional organization across the adult lifespan and in age-related neurodegenerative disease remained open. The aim of this cross-sectional study was to identify the spatial pattern of hippocampus differentiation based on structural covariance with a data-driven approach across structural MRI data of large cohorts (n = 2594). We examined the pattern of structural covariance of hippocampus voxels in young, middle-aged, elderly, mild cognitive impairment and dementia disease samples by applying a clustering algorithm revealing differentiation in structural covariance within the hippocampus. In all the healthy and in the mild cognitive impaired participants, the hippocampus was robustly divided into anterior, lateral and medial subregions reminiscent of cytoarchitectonic division. In contrast, in dementia patients, the pattern of subdivision was closer to known functional differentiation into an anterior, body and tail subregions. These results not only contribute to a better understanding of co-plasticity and co-atrophy in the hippocampus across the lifespan and in dementia, but also provide robust data-driven spatial representations (i.e. maps) for structural studies.
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