Evidence map›Paper›PMID 32851330›Full record

ArticlePediatric investigation2019

Clinical research study designs: The essentials.

Ambika G Chidambaram, Maureen Josephson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  11. ESMO Guidance for Reporting Oncology real-World evidence (GROW).ESMO real world data and digital oncology · 2023
    Article
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  18. Reply to: Effects of partly supervised and home-based exercise program in patients undergoing hematopoietic stem cell transplantation: a case-control study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ambika G ChidambaramChildren's Hospital of Philadelphia Philadelphia Pennsylvania USA.
Maureen JosephsonChildren's Hospital of Philadelphia Philadelphia Pennsylvania USA.
Children's Hospital of Philadelphia · US

Funding

CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM008562 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WALTER K KRAFT, Scott A. Waldman · 1995 to 2026
$10.2M
NIGMS NIH HHS T32 GM008562
6 · The paper itself

Abstract

In clinical research, our aim is to design a study which would be able to derive a valid and meaningful scientific conclusion using appropriate statistical methods. The conclusions derived from a research study can either improve health care or result in inadvertent harm to patients. Hence, this requires a well-designed clinical research study that rests on a strong foundation of a detailed methodology and governed by ethical clinical principles. The purpose of this review is to provide the readers an overview of the basic study designs and its applicability in clinical research.

Indexed as

Clinical research study designClinical trialsExperimental study designsObservational study designsRandomization

Identifiers

PMID32851330
PMCPMC7331444
OpenAlexW2996045874

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.