ArticlePediatric investigation2019
The value of nasal nitric oxide measurement in the diagnosis of primary ciliary dyskinesia.
Article in Pediatric investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Primary Ciliary Dyskinesia: A Clinical Review.Cells · 2024Review
- TheInternational journal of molecular sciences · 2023Review
- Long-Term Azithromycin Treatment in Pediatric Primary Ciliary Dyskinesia: A Retrospective Study.Frontiers in pediatrics · 2022Article
- Emerging Genotype-Phenotype Relationships in Primary Ciliary Dyskinesia.International journal of molecular sciences · 2021Review
- Clinical characteristics and genetic spectrum of 26 individuals of Chinese origin with primary ciliary dyskinesia.Orphanet journal of rare diseases · 2021Article
- NO donors and NO delivery methods for controlling biofilms in chronic lung infections.Applied microbiology and biotechnology · 2021Review
- Article
- The value of nasal nitric oxide measurement in the diagnosis of primary ciliary dyskinesia.Pediatric investigation · 2019Article
- Nasal nitric oxide measurement for primary ciliary dyskinesia diagnosis: The impact of underlying genetic defects on diagnostic accuracy.Pediatric investigation · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceNasal nitric oxide (nNO) testing is a method used in the diagnosis of primary ciliary dyskinesia (PCD). It has not been evaluated in Chinese population.
objectiveTo establish a reference nNO value to assist in the diagnosis of PCD in Chinese children.
methodsnNO values were measured in children with PCD (
resultsnNO values were significantly lower in children with PCD (median 25.66 nL/min) than in children with asthma (186.26 ± 58.95 nL/ min), BO (143.47 ± 49.71 nL/min) and non-PCD/non-CF bronchiectasis (173.13 ± 63.80 nL/min), but not in children with CF (90.90 ± 43.20 nL/min). Notably however, no CF patient had an nNO value < 45 nL/min. A cut-off of 76 nL/min yielded the best sensitivity of 86.1%, and specificity of 91.4%, with an area under the curve of 0.920 (95% confidence interval 0.859-0.981) for the diagnosis of PCD. If CF was ruled out the specificity increased to nearly 100%.
interpretationnNO testing is able to discriminate between patients with PCD and those with CF, asthma, post-infectious BO and non-PCD/non-CF bronchiectasis. A cut-off of 76 nL/min could be further examined in patients suspected of PCD, to establish an nNO reference value for PCD screening in Chinese children.
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