ArticlePediatric investigation2019
Surfactant protein C dysfunction with new clinical insights for diffuse alveolar hemorrhage and autoimmunity.
Article in Pediatric investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Old and emerging therapies for childhood interstitial lung disease (chILD): a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- A rare interstitial lung disease in young adulthood due to surfactant protein C gene mutation: Two case reports with brief literature review.Radiology case reports · 2025Article
- [Current Status of and Challenges in Diagnosis and Treatment of Childhood Diffuse Parenchymal Lung Diseases/Childhood Interstitial Lung Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2021Review
- Genetic testing for rare pediatric lung disorders: The promise and the pitfalls.Pediatric investigation · 2020Article
- New insights into pulmonary hemorrhage.Pediatric investigation · 2019Article
- Surfactant protein C dysfunction with new clinical insights for diffuse alveolar hemorrhage and autoimmunity.Pediatric investigation · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceSurfactant protein C (SP-C) dysfunction is a rare disease associated with interstitial lung disease. Early therapies may improve outcomes but the diagnosis is often delayed owing to variability of manifestations.
objectiveTo investigate the manifestations and outcomes of SP-C dysfunction.
methodsWe retrospectively analyzed the records of five pediatric patients who were diagnosed with SP-C dysfunction between February 2014 and April 2017 at Beijing Children's Hospital.
resultsThe five patients included two boys and three girls with a median age at diagnosis of 1.3 years. All patients presented with interstitial lung disease and had a heterozygous
interpretationThis is the first report to describe a new phenotype of diffuse alveolar hemorrhage with autoimmunity in patients with I73T
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Registered trials
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