ArticlePediatric investigation2019
Implications of hepatic dysfunction in Kawasaki disease: Time-related changes in aspartate aminotransferase, alanine aminotransferase, total bilirubin, and C-reactive protein levels.
Article in Pediatric investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Beyond biochemical recovery: rethinking liver dysfunction in Kawasaki disease.Translational pediatrics · 2026Article
- Biochemical outcomes and safety profiles of compound glycyrrhizin versus magnesium isoglycyrrhizinate in Kawasaki disease: a retrospective propensity score‑matched cohort study.Translational pediatrics · 2026Article
- Enhanced heterotrophic β-glucan production from a UV-induced Euglena gracilis mutant screened using a novel method under optimized cultivation conditions.Biotechnology for biofuels and bioproducts · 2025Article
- Nutrition-Associated Biomarkers in Predicting Intravenous Immunoglobulin Resistance and Coronary Artery Lesions in Kawasaki Disease: A Systematic Review and Meta-Analysis.Food science & nutrition · 2025Review
- Diagnostic value of syndecan-1 for coronary artery lesions and correlation analysis of laboratory indicators in Kawasaki disease patients.Italian journal of pediatrics · 2024Article
- Predicting Kawasaki disease shock syndrome in children.Frontiers in immunology · 2024Article
- Kawasaki disease in Malaysia: Biochemical profile, characterization, diagnosis and treatment.Frontiers in pediatrics · 2022Article
- AST-to-ALT ratio and coronary artery lesions among patients with Kawasaki disease.World journal of pediatrics : WJP · 2021Article
- Atypically Protracted Course of Liver Involvement in Kawasaki Disease. Case Report and Literature Review.Pediatric reports · 2021Article
- Implications of hepatic dysfunction in Kawasaki disease: Time-related changes in aspartate aminotransferase, alanine aminotransferase, total bilirubin, and C-reactive protein levels.Pediatric investigation · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
importanceThe cause of the hepatic dysfunction that commonly accompanies Kawasaki disease (KD) remains unclear.
objectiveWe tried to clarify the cause of the hepatic dysfunction.
methodsA total of 381 consecutive patients with acute KD, who had undergone inpatient treatment with intravenous immunoglobulin until the 7th day of illness, were divided into a group of 199 patients with an alanine aminotransferase (ALT) level ≥ 40 IU/L on admission (group I), a group of 52 patients with an ALT level ≥ 40 IU/L at some point after admission (group II), and a group of 130 patients with ALT levels consistently < 40 IU/L throughout hospitalization (group III). Aspartate aminotransferase (AST), ALT, total bilirubin (T-Bil), and C-reactive protein (CRP) levels were analyzed over time, and time-courses were compared.
resultsIn the initial stage of illness, in group I, AST, ALT, T-Bil peaked on days 1-3, and AST tended to improve significantly on the 4th day (
interpretationRecovery from liver dysfunction occurred in the initial stage of illness in group I-within the period of CRP exacerbation, which is an indicator of systemic inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.