ArticlePediatric investigation2018
Causes and manifestations of chylothorax in children in China: Experience from a children's medical center, 2007-2017.
Article in Pediatric investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Lymphatic plastic bronchitis and primary chylothorax: A study based on computed tomography lymphangiography.World journal of clinical cases · 2024Article
- A case report of successful therapy for neonatal chylothorax with pneumothorax by conservative medical treatment.Translational pediatrics · 2023Article
- Evaluation of Clinical Findings in Children with Chylothorax: A Descriptive Study.Turkish archives of pediatrics · 2023Article
- Non-immune hydrops fetalis secondary to congenital chylothorax with diffuse interstitial lung disease: a diagnostic conundrum.BMJ case reports · 2021Article
- Reply to "Causes and manifestation of chylothorax in children".Pediatric investigation · 2018Article
- Causes and manifestations of chylothorax in children.Pediatric investigation · 2018Article
- Chylothorax in infants and children in China, a very good start.Pediatric investigation · 2018Article
- Causes and manifestations of chylothorax in children in China: Experience from a children's medical center, 2007-2017.Pediatric investigation · 2018Article
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5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
importanceChylothorax is the most common cause of pleural effusion in neonates and relatively rare in children. It can cause significant respiratory morbidity. Many clinical entities may contribute to chylothorax.
objectiveTo investigate the causes and manifestations of chylothorax in infants and children in China.
methodsCase records of 107 cases with chylothorax seen in Beijing Children's Hospital from 2007 to 2017 were retrieved and analyzed; follow-up was carried out by telephone.
resultsOf 107 cases, 58.9% (63/107) were primary chylothorax (PC) and 41.1% (44/107) were secondary chylothorax (SC). Also, 36.4% (39/107) were neonatal chylothorax (NC) and 35.5% (38/107) were postoperative chylothorax. In PC with a verified lymphatic anomaly, there was one case of diffuse pulmonary lymphangiomatosis (DPL) and six cases of generalized lymphatic anomaly (GLA), which accounted for 6.5% (7/107) of cases. In most patients, chylothorax was alleviated by conservative treatment based on total parenteral nutrition (TPN); 13.1% (14/107) of cases needed further surgery. In NC, the median duration of TPN was 9 days, but 10 of 20 cases who improved had recurrence upon re-introduction of a fat-free diet, which was alleviated by further TPN. The duration of hospitalization was (23 ± 14) days for congenital chylothorax. Upon long- term follow-up, except for GLA and DPL, most patients were doing well without recurrence.
interpretationNC and postoperative chylothorax are the common subtypes. TPN is effective for most patients. Despite a prolonged and fluctuating clinical course, most patients had a good long-term prognosis.
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