ArticleScience advances2020
The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor.
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Pooled it
- Multimodal imaging reveals no evidence for magnetite-based magnetoreceptors in the mole-rat eye.iScience · 2026Article
- Protocol for whole-brain immunolabeling, clearing, and light-sheet imaging of C-FOS in the pigeon.STAR protocols · 2026Article
- A Charge-Reversal Point Mutation Completely Depletes Flavin Chromophore from European Robin Cryptochrome 4a Protein.The journal of physical chemistry letters · 2026Article
- A hybrid compass mechanism combining radical pairs and magnetite crystals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception.iScience · 2025Article
- Protein and Solvent Reorganization Drives Radical Pair Stability in Avian Cryptochrome 4a.Journal of the American Chemical Society · 2025Article
- Cryptochrome 4b protein is probably irrelevant for radical pair-based magnetoreception in the European robin.Journal of the Royal Society, Interface · 2025Article
- Linear free energy relationship between reduction potential and photoreduction rate: studies on Drosophila cryptochrome.The FEBS journal · 2025Article
- Spectroscopic Characterization of Radical Pair Photochemistry in Nonmigratory Avian Cryptochromes: Magnetic Field Effects inJournal of the American Chemical Society · 2025Article
- Direct observation of long-lived radical pair between flavin and guanine in single- and double-stranded DNA-oligomers.Communications chemistry · 2025Article
- Teacups, a Python Package for the Simulation of Time-Resolved EPR Spectra of Spin-Polarized Multi-Spin Systems.The journal of physical chemistry. A · 2025Article
- European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception.ACS chemical biology · 2025Article
- Interplay of Light, Melatonin, and Circadian Genes in Skin Pigmentation Regulation.Pigment cell & melanoma research · 2025Article
- Magnetic sense-dependent probabilistic decision-making in humans.Frontiers in neuroscience · 2025Article
- Cryptochrome magnetoreception: Time course of photoactivation from non-equilibrium coarse-grained molecular dynamics.Computational and structural biotechnology journal · 2024Article
- Comparison of retinol binding protein 1 with cone specific G-protein as putative effector molecules in cryptochrome signalling.Scientific reports · 2024Article
- Performance Evaluation of a Bioinspired Geomagnetic Sensor and Its Application for Geomagnetic Navigation in Simulated Environment.Sensors (Basel, Switzerland) · 2024Article
- Understanding the Red Shift in the Absorption Spectrum of the FAD Cofactor in ClCry4 Protein.The journal of physical chemistry. B · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 9 institutions in 4 countries.
Funding
Abstract
The biophysical and molecular mechanisms that enable animals to detect magnetic fields are unknown. It has been proposed that birds have a light-dependent magnetic compass that relies on the formation of radical pairs within cryptochrome molecules. Using spectroscopic methods, we show that pigeon cryptochrome clCRY4 is photoreduced efficiently and forms long-lived spin-correlated radical pairs via a tetrad of tryptophan residues. We report that clCRY4 is broadly and stably expressed within the retina but enriched at synapses in the outer plexiform layer in a repetitive manner. A proteomic survey for retinal-specific clCRY4 interactors identified molecules that are involved in receptor signaling, including glutamate receptor-interacting protein 2, which colocalizes with clCRY4. Our data support a model whereby clCRY4 acts as an ultraviolet-blue photoreceptor and/or a light-dependent magnetosensor by modulating glutamatergic synapses between horizontal cells and cones.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.