ArticleScience advances2020
Epithelial cell-specific loss of function of
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Analysis of the Clinical Efficacy and Molecular Mechanism of Xuefu Zhuyu Decoction in the Treatment of COPD Based on Meta-Analysis and Network Pharmacology.Computational and mathematical methods in medicine · 2022Pooled it
- ZBTB17/MIZ1 promotes peroxisome biogenesis by transcriptional regulation of PEX13.The Journal of cell biology · 2025Article
- CT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD.Military Medical Research · 2024Article
- Silencing KLF6 Alleviates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction in Bronchial Epithelial Cells by SIRT4 Upregulation.International journal of chronic obstructive pulmonary disease · 2024Article
- Suppression of interferon α and γ response by Huwe1-mediated Miz1 degradation promotes SARS-CoV-2 replication.Frontiers in immunology · 2024Article
- Lactobacillus rhamnosus Restores Antiviral Signaling and Attenuates Cytokines Secretion from Human Bronchial Epithelial Cells Exposed to Cigarette Smoke and Infected with SARS-CoV-2.Probiotics and antimicrobial proteins · 2023Article
- ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification.Journal of biomedical science · 2023Review
- Wnt3a-Loaded Extracellular Vesicles Promote Alveolar Epithelial Regeneration after Lung Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Suppression of Allergic Asthma by Loss of Function of Miz1-mediated Th1 Skewing.American journal of respiratory cell and molecular biology · 2022Article
- Bergamottin protects against LPS-induced endotoxic shock by regulating the NF-κB signaling pathway.Immunologic research · 2022Article
- Integrin-β4 regulates the dynamic changes of phenotypic characteristics in association with epithelial-mesenchymal transition (EMT) and RhoA activity in airway epithelial cells during injury and repair.International journal of biological sciences · 2022Article
- Identification of Small Airway Epithelium-Related Hub Genes in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2022Article
- miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury.Frontiers in immunology · 2021Article
- Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.Frontiers in immunology · 2021Article
- Innate Immune Responses and Pulmonary Diseases.Advances in experimental medicine and biology · 2021Article
- ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 6 institutions in 2 countries.
Hanh Chi Do-UmeharaDepartment of Surgery, College of Medicine and University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-3368-1602
Cong ChenDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Qiao ZhangDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Alexander V MisharinDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-2879-3789
Hiam Abdala-ValenciaDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-3384-5299
S Marina Casalino-MatsudaDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Paul A ReyfmanDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-6435-6001
Kishore R AnekallaDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-8366-5782
Francisco J Gonzalez-GonzalezDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Marc A SalaDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Chao PengNational Facility for Protein Science in Shanghai, Zhangjiang Lab, SARI, CAS, Shanghai 201210, China.ORCID 0000-0002-6814-2676
Ping WuNational Facility for Protein Science in Shanghai, Zhangjiang Lab, SARI, CAS, Shanghai 201210, China.ORCID 0000-0001-9765-9570
Catherine C L WongPeking University School of Pharmaceutical Science, Beijing 100191, China.
Ravi KalhanDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0003-2443-0876
Ankit BharatDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Harris PerlmanDivision of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Karen M RidgeDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-2089-4764
Peter H S SpornDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-1006-9437
Navdeep S ChandelDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-7208-3886
Jindan YuDivision of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Xiangdong FuDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA; Institute of Genomic Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA.
Irina PetracheNational Jewish Health, 1400 Jackson Street, Molly Blank Building, J203, Denver, CO 80206, USA.
Rubin TuderUniversity of Colorado at Denver Health Sciences Center, Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Denver, CO 80206, USA.
G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-3114-5208
Jing LiuDepartment of Surgery, College of Medicine and University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-4699-1375
Northwestern University · USShanghai Zhangjiang Laboratory · CNUniversity of Colorado Hospital · USUniversity of Illinois Chicago · USPeking University · CNUniversity of California San Diego · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MRole of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2003 to 2019
$30.8MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9MTechnology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUIS A. Nunes AMARAL · 2018 to 2026
$24.7MTransitions from Impaired Respiratory Health to Lung DiseaseR01HL122477 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAVI KALHAN · 2014 to 2026
$17.3MTraining Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6MRole of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgeryR01HL147575 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.5MPathogenesis of lung injury mediated by lung-restricted antibodiesR01HL147290 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.2MDonor nonclassical monocytes mediate primary graft dysfunction and remote organ injury following lung transplant surgeryR01HL145478 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$4.8MSignaling in the lung induced by particulate matter air pollutionR01ES013995 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT · 2006 to 2015
$3.3MMacrophage Modulation of Lung FibrosisR01HL134375 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PERLMAN, HARRIS R · 2017 to 2020
$2.9MThe transcription factor Miz1-mediated mechanisms of lung agingR01HL141459 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIU, JING · 2018 to 2021
$2.0MBLRD VA I01 BX000201NCI NIH HHS P30 CA060553NHLBI NIH HHS K08 HL146943NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL114763NHLBI NIH HHS R01 HL122477NHLBI NIH HHS R01 HL131745NHLBI NIH HHS R01 HL134375NHLBI NIH HHS R01 HL141459NHLBI NIH HHS R01 HL145478NHLBI NIH HHS R01 HL147290NHLBI NIH HHS R01 HL147575NHLBI NIH HHS T32 HL076139NIAID NIH HHS U19 AI135964NIA NIH HHS P01 AG049665NIEHS NIH HHS R01 ES013995NIH HHS AG049665NIH HHS AI135964NIH HHS ES013995NIH HHS HL071643NIH HHS HL 114763NIH HHS HL 141459NIH HHS HL145478NIH HHS HL147290NIH HHS HL147575
Abstract
Cigarette smoking, the leading cause of chronic obstructive pulmonary disease (COPD), has been implicated as a risk factor for severe disease in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we show that mice with lung epithelial cell-specific loss of function of
Indexed as
PhenotypeAngiotensin-Converting Enzyme 2AnimalsBetacoronavirusCoronavirus InfectionsCOVID-19Epithelial CellsGene Knockout TechniquesHumansKruppel-Like Transcription FactorsLungMiceMice, Inbred C57BLMice, KnockoutPandemicsPeptidyl-Dipeptidase AACE2 protein, humanAce2 protein, mouseAngiotensin-Converting Enzyme 2Kruppel-Like Transcription FactorsMiz1 protein, mousePeptidyl-Dipeptidase AProtein Inhibitors of Activated STATRela protein, mouseTranscription Factor RelAUbiquitin-Protein LigasesZBTB17 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.