ArticleOrthopaedic journal of sports medicine2020
Higher Body Mass Index Is Associated With Biochemical Changes in Knee Articular Cartilage After Marathon Running: A Quantitative T2-Relaxation MRI Study.
Article in Orthopaedic journal of sports medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Acute changes in knee cartilage and meniscus following long-distance running in habituate runners: a systematic review on studies using quantitative magnetic resonance imaging.Skeletal radiology · 2022Pooled it
- The Influence of Running on Lower Limb Cartilage: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Region-, zone-, and layer-specific knee cartilage T2 relaxation patterns in sports-active adolescents.European radiology · 2026Article
- Associations Between Patient Characteristics and Cartilage T1ρ Relaxation Times Vary Over Time Following Patellar Dislocation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Patellofemoral Cartilage Degradation Based on T1ρ Relaxation Times Varies Inversely With BMI After Patellar Dislocation.Orthopaedic journal of sports medicine · 2025Article
- Medial Compartment Knee Osteoarthritis Altered Tibiofemoral Joint Kinematics and Contact Pattern During Daily Weight-Bearing Extension.Orthopaedic surgery · 2025Article
- Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage.Osteoarthritis and cartilage open · 2025Article
- HKA angle exceeding 5 degrees is strongly associated with lateral patellar translation beyond 2 mm: surgical recommendations for avoiding adverse effects on the patellofemoral joint after OWHTO.Journal of orthopaedic surgery and research · 2025Article
- Article
- Imaging of joint response to exercise with MRI and PET.Skeletal radiology · 2023Review
- Periodical assessment of four horns of knee meniscus using MR T2 mapping imaging in volunteers before and after amateur marathons.Scientific reports · 2022Article
- Obesity impacts the mechanical response and biochemical composition of patellofemoral cartilage: An in vivo, MRI-based investigation.Journal of biomechanics · 2022Article
- Analysis of Knee Joint Injury Caused by Physical Training of Freshmen Students Based on 3T MRI and Automatic Cartilage Segmentation Technology: A Prospective Study.Frontiers in endocrinology · 2022Article
- Variation characteristics of stress distribution in the subchondral bone of the knee joint of judo athletes with long-term stress changes.Frontiers in endocrinology · 2022Article
- Magnetic resonance imaging for non-invasive clinical evaluation of normal and regenerated cartilage.Regenerative biomaterials · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMore than 30 million individuals participate in marathon running every year worldwide. As the popularity of marathon running continues to increase, it is essential for the purposes of injury prevention to understand the effects of marathon running on the knee cartilage. PURPOSE: To investigate the immediate effects of marathon running on knee articular cartilage and to determine the relationship between body mass index and cartilage biochemical composition. STUDY
designDescriptive laboratory study.
methodsT2-relaxation magnetic resonance imaging (MRI) of knees in 18 nonprofessional marathoners (mean age, 35.6 ± 6.4 years) was performed before and after a full-length marathon. Three-dimensional models of the knee articular cartilage were reconstructed and divided into different regions of interest. The 3-dimensional models were then applied to corresponding T2-relaxation MRI maps to calculate T2 values in each region of interest. The mean values of the T2-relaxation times in each region of interest before and after the marathon were compared by use of the paired Student
resultsPostmarathon T2-relaxation times were significantly higher than premarathon values for patellofemoral cartilage (32.6 ± 12.1 vs 34.1 ± 10.9 ms;
conclusionMarathon running leads to immediate postmarathon elevated T2-relaxation values within knee articular cartilage, suggesting biochemical content alteration. Additionally, runners with higher BMI may have greater changes in cartilage biochemical composition after a marathon. Further studies should investigate whether these changes are sustained over time to determine the relationship between immediate biochemical changes in cartilage composition and cartilage degeneration. CLINICAL RELEVANCE: Runners with a higher BMI may carry a higher risk of anteromedial tibiofemoral cartilage degeneration compared with runners with lower BMI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.