Evidence map›Paper›PMID 32850961›Full record

ReviewFrontiers in molecular biosciences2020

miRNAs in Adipocyte-Derived Extracellular Vesicles: Multiple Roles in Development of Obesity-Associated Disease.

Yaliang Zhou, Chunlu Tan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in molecular biosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Next-Cell Hypothesis: Mechanism of Obesity-Associated Carcinogenesis.Advances in experimental medicine and biology · 2024
    Review
  8. MicroRNAs as Epigenetic Regulators of Obesity.Advances in experimental medicine and biology · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Peripheral and central macrophages in obesity.Frontiers in endocrinology · 2023
    Review
  13. Review
  14. Review
  15. The impact of obesity on adipocyte-derived extracellular vesicles.Cellular and molecular life sciences : CMLS · 2021
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yaliang ZhouDepartment of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Chunlu TanDepartment of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity and overweight are common modern health challenges. Caloric intake greater than that needed for energy production results in excess storage of fat in the abdomen. Visceral fat secretes a wide spectrum of adipokines, and increased adiposity is associated with a higher risk of development of metabolic disorders. In addition, adipose tissue secretes extracellular vesicles (EVs) to communicate with peripheral cells and distant organs, and regulate whole-body metabolism. Furthermore, clinical evidence has shown that adipose tissue-derived EVs are present at low levels in the circulation of healthy individuals. In contrast, individuals with metabolic syndrome have significantly higher levels of circulating adipose-derived EVs. The composition of the contents of EVs is dynamic, and closely mirrors individual daily habits and fasting-fed state metabolic characteristics. In this mini-review, we aimed to elucidate the role of adipocyte-derived EVs in regulation of whole-body metabolism under physiological and pathophysiological conditions. Studies have shown that adipose tissue may be a major source of circulating exosomal miRNAs that regulate metabolic homeostasis and directly promote insulin-resistance in other organs. Furthermore, the composition of adipocyte-derived circulating miRNAs in EVs may change prior to development of metabolic disorder. Adipocyte-derived miRNAs in EVs may also induce obesity-related changes such as M1 polarization and inhibition of M2 polarization of macrophages, which may affect the biological behaviors of surrounding tumor cells.

Indexed as

adiposeextracellular vesiclesmiRNAsobesityobesity-associated disease

Identifiers

PMID32850961
PMCPMC7403463
OpenAlexW3045990797

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.