Evidence map›Paper›PMID 32850906›Full record

ArticleFrontiers in medicine2020

An Investigation Into the Prognostic Significance of High Proteasome PSB7 Protein Expression in Colorectal Cancer.

Ju-Yoon Yoon, Julia Y Wang, Michael H A Roehrl

Abstract read
In one paragraph

Article in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ju-Yoon YoonDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, United States.
Julia Y WangCurandis, New York, NY, United States.
Michael H A RoehrlDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Proteomic Characterization of Genomically Complex SarcomasR21CA251992 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ROEHRL, MICHAEL H. A. · 2020 to 2020
$487k
Targeting Multiple Colorectal Cancer-Specific EnhancersR21CA231109 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PTASHNE, MARK S · 2019 to 2020
$430k
NCI NIH HHS P30 CA008748NCI NIH HHS R21 CA231109NCI NIH HHS R21 CA251992
6 · The paper itself

Abstract

Using unbiased proteomics, we had previously discovered that the catalytic proteasome subunit β type 7 (PSB7) protein is frequently overexpressed in colorectal adenocarcinomas. In this paper, we validate this finding and derive a prognostic significance for PSB7 by examining an expanded, well-annotated clinical cohort of 318 colorectal cancer patients. We found PSB7 protein levels to be similarly increased in both advanced stage primary disease and metastatic lesions. We then examined the prognostic value of PSB7 protein expression. Elevated PSB7 protein as well as

Indexed as

biomarkercolorectal canceroncologyprognosisproteasomeprotein expressionPSB7

Identifiers

PMID32850906
PMCPMC7426439

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.