Evidence map›Paper›PMID 32850728›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Acoustic Radiation or Cavitation Forces From Therapeutic Ultrasound Generate Prostaglandins and Increase Mesenchymal Stromal Cell Homing to Murine Muscle.

Rebecca M Lorsung, Robert B Rosenblatt, Gadi Cohen, Joseph A Frank, Scott R Burks

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rebecca M LorsungFrank Laboratory, Department of Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, United States.
Robert B RosenblattFrank Laboratory, Department of Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, United States.
Gadi CohenFrank Laboratory, Department of Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, United States.
Joseph A FrankFrank Laboratory, Department of Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, United States.
Scott R BurksFrank Laboratory, Department of Radiology and Imaging Sciences, NIH Clinical Center, Bethesda, MD, United States.
National Institutes of Health Clinical Center · USNational Institute of Biomedical Imaging and Bioengineering · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-ablative ultrasound (US)-based techniques to improve targeted tropism of systemically infused cell therapies, particularly mesenchymal stromal cell (MSC), have gained attention in recent years. Mechanotransduction following targeted US sonications have been shown to modulate tissue microenvironments by upregulating cytokines, chemokines, and trophic factors in addition to vascular cell adhesion molecules (CAM) that are necessary to promote tropism of MSC. While numerous US treatment parameters have demonstrated increased MSC homing, it remains unclear how the different mechanical US forces [i.e., acoustic radiation forces (ARF) or cavitation forces] influence tissue microenvironments. This study sonicated murine muscle tissue with pulsed focused ultrasound (pFUS) at 0.5 or 1.15 MHz each over a range of US intensities. Following sonication, tissue was assayed for the prostaglandins (PG) PGH

Indexed as

acoustic radiation forcecavitationcell therapylow intensity pulsed ultrasoundmesenchymal stromal cellprostaglandinpulsed focused ultrasoundregenerative medicine

Identifiers

PMID32850728
PMCPMC7399074
OpenAlexW3046119448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.