ReviewFrontiers in pediatrics2020
Current Insights on Early Life Nutrition and Prevention of Allergy.
Review in Frontiers in pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Early-life high-dose omega-3 polyunsaturated fatty acid supplementation reduces risk of childhood asthma/wheezing: A meta-analysis of randomized controlled trials.Asia Pacific journal of clinical nutrition · 2026Pooled it
- An Unhealthy Start: The Nutritional Composition, Processing, and on-Pack Claims of Commercial Foods for Infants and Toddlers in Thailand.Maternal & child nutrition · 2026Article
- A Rare Case of Cow's Milk Protein Allergy in a 12-Hour Old Neonate With Rectal Bleeding.Case reports in pediatrics · 2026Article
- The impact of maternal health and lifestyle on low birth weight: a prospective cohort study.Italian journal of pediatrics · 2025Article
- Gastrointestinal Disorders and Atopic Dermatitis in Infants in the First Year of Life According to ROME IV Criteria-A Possible Association with the Mode of Delivery and Early Life Nutrition.Journal of clinical medicine · 2024Article
- Gut microbiota markers in early childhood are linked to farm living, pets in household and allergy.PloS one · 2024Article
- The First 1000 Days of Life: How Changes in the Microbiota Can Influence Food Allergy Onset in Children.Nutrients · 2023Review
- The Effectiveness of Early Food Introduction in Preventing Childhood Allergic Diseases: Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2023Article
- Dietary Intake by Toddlers and Preschool Children: Preliminary Results from a Michigan Cohort.Children (Basel, Switzerland) · 2023Article
- Association between household income levels and nutritional intake of allergic children under 6 years of age in Korea: 2019 Korea National Health and Nutrition Examination Survey and application of machine learning.Frontiers in public health · 2023Article
- Nutrition, Gut Microbiota, and Allergy Development in Infants.Nutrients · 2022Review
- Composition of Human Breast Milk Microbiota and Its Role in Children's Health.Pediatric gastroenterology, hepatology & nutrition · 2022Article
- Non-Cholesterol Sterols in Breast Milk and Risk of Allergic Outcomes in the First Two Years of Life.Nutrients · 2022Article
- The potential role of preventive and therapeutic immunonutrition strategies for pediatric food allergy: A mini-review.Frontiers in nutrition · 2022Review
- Analysis of risk and prognostic factors in a population of pediatric patients hospitalized for acute malnutrition at the Chiulo hospital, Angola.Italian journal of pediatrics · 2021Article
- Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of allergic diseases in childhood appears to have significantly increased over the last decades. Since environmental factors, including diet, have been thought to play a significant role in the development of these diseases, there is great interest in identifying prevention strategies related to early nutritional interventions. Breastfeeding is critical for the immune development of newborns and infants through immune-modulating properties and it impacts the establishment of a healthy gut microbiota. However, the evidence for a protective role of breastfeeding against the development of food allergy in childhood is controversial, and there is little evidence to support the benefits of an antigen avoidance diet during lactation. Although it is not possible to draw a definitive conclusion about the protective role of breast milk against allergic diseases, exclusive breastfeeding is still recommended throughout the first 6 months of life due to associated health benefits. Furthermore, recommendations regarding complementary feeding in infancy have been significantly modified over the last few decades. Several studies have shown that delayed exposure to allergenic foods does not have a role in allergy prevention and recent guidelines recommend against delaying the introduction of complementary foods after 6 months of age, both in high- and low-risk infants. However, trials investigating this dietary approach have reported equivocal results so far. This review summarizes the available high-quality evidence regarding the efficacy of the principal dietary interventions proposed in early life to prevent allergic diseases in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.