ArticleIranian journal of otorhinolaryngology2020
Effects of Gabapentin Suspension and Rectal Acetaminophen on Postoperative Pain of Adenotonsillectomy in Children.
Article in Iranian journal of otorhinolaryngology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- [Clinical practice guideline for perioperative pain management in pediatric low-temperature plasma tonsillectomy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Guideline
- Seeking a viable perioperative preemptive analgesia regimen: a prospective, randomized, controlled, double-blind superiority study of intravenous acetaminophen in children undergoing adenotonsillectomy.Frontiers in pediatrics · 2026Trial
- Gabapentinoids for Upper Airway Surgery Pain Management: Systematic Review and Meta-Analysis.Laryngoscope investigative otolaryngology · 2026Article
- Perioperative gabapentin usage in pediatric patients: A scoping review.Paediatric anaesthesia · 2023Article
- A scoping review of randomized clinical trials for pain management in pediatric tonsillectomy and adenotonsillectomy.World journal of otorhinolaryngology - head and neck surgery · 2023Article
- Impact of intravenous administration of nalbuphine at different time points for postoperative analgesia and sedation in adenotonsillectomized children: a prospective, randomized controlled trial.World journal of pediatric surgery · 2023Article
- Perioperative Indications for Gabapentinoids in Pediatrics: A Narrative Review.Paediatric drugs · 2023Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAdenotonsillectomy is the main treatment for symptomatic tonsillar hypertrophy with postoperative pain as the most common associated complication. The present study aimed to compare the efficacy of gabapentin with that reported for acetaminophen on the postoperative pain of adenotonsillectomy in children. MATERIALS AND
methodsIn this double-blind clinical trial, a total of 60 children within the age range of 7-15 years undergoing adenotonsillectomy were randomly allocated to two groups of gabapentin (n=30) and acetaminophen (n=30). The first group received a 10 mg/kg dose of gabapentin suspension preoperatively and placebo (suppository) after the intubation. The second group received a 40 mg/kg dose of acetaminophen suppository and placebo suspension simultaneous with that in the case group. Using the pain scale (based on the score of visual analog scale, prescribed drugs, dosage as well as incidence of postoperative nausea and vomiting were recorded 0, 2, 4, 6, 12, and 24 h after the surgery. The data were analyzed using SPSS software (version 22.0). A p-value less than 0.05 was considered statistically significant.
resultsThere was no significant difference between the two groups considering the pain scores at 0, 2, 4, 6, 12, and 24 h after the surgery. In addition, the trend of pain intensity statistically decreased within 0 to 24 h in both acetaminophen (P<0.001) and gabapentin (P<0.001) groups. No statistically significant difference was observed between the two groups regarding the postoperative incidence of nausea and vomiting.
conclusionThe obtained results of the present study showed that the administration of gabapentin and acetaminophen significantly reduced the postoperative pain of tonsillectomy and need for narcotics in these patients after the surgery. However, in this study, there was no particular reported superiority for any of the two groups in terms of the effects of gabapentin suspension and rectal acetaminophen.
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