Evidence map›Paper›PMID 32850458›Full record

ArticleFrontiers in oncology2020

Impairment of Base Excision Repair in Dermal Fibroblasts Isolated From Nevoid Basal Cell Carcinoma Patients.

Aurélie Charazac, Nour Fayyad, David Beal, Sandrine Bourgoin-Voillard, Michel Seve, Sylvie Sauvaigo, Jérôme Lamartine, Pascal Soularue, Sandra Moratille, Michèle T Martin and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. A case of nevoid basal cell carcinoma syndrome dominated by facial basal cell carcinoma.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Aurélie CharazacSYMMES/CIBEST UMR 5819 UGA-CNRS-CEA, Univ. Grenoble Alpes, Grenoble, France.
Nour FayyadSYMMES/CIBEST UMR 5819 UGA-CNRS-CEA, Univ. Grenoble Alpes, Grenoble, France.
David BealSYMMES/CIBEST UMR 5819 UGA-CNRS-CEA, Univ. Grenoble Alpes, Grenoble, France.
Sandrine Bourgoin-VoillardLBFA and BEeSy, PROMETHEE Proteomic Platform, Université Grenoble Alpes, Grenoble, France.
Michel SeveLBFA and BEeSy, PROMETHEE Proteomic Platform, Université Grenoble Alpes, Grenoble, France.
Sylvie SauvaigoLXRepair, La Tronche, France.
Jérôme LamartineCNRS UMR 5305, Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, Lyon, France.
Pascal SoularueLaboratoire de Génomique et Radiobiologie de la Kératinopoïèse, CEA/DRF/IBFJ/IRCM, Université Paris-Saclay, Evry, France.
Sandra MoratilleLaboratoire de Génomique et Radiobiologie de la Kératinopoïèse, CEA/DRF/IBFJ/IRCM, Université Paris-Saclay, Evry, France.
Michèle T MartinLaboratoire de Génomique et Radiobiologie de la Kératinopoïèse, CEA/DRF/IBFJ/IRCM, Université Paris-Saclay, Evry, France.
Jean-Luc RavanatSYMMES/CIBEST UMR 5819 UGA-CNRS-CEA, Univ. Grenoble Alpes, Grenoble, France.
Thierry DoukiSYMMES/CIBEST UMR 5819 UGA-CNRS-CEA, Univ. Grenoble Alpes, Grenoble, France.
Walid RachidiSYMMES/CIBEST UMR 5819 UGA-CNRS-CEA, Univ. Grenoble Alpes, Grenoble, France.
Université Grenoble Alpes · FRCentre National de la Recherche Scientifique · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRAgence de la transition écologique · FRBiologie Tissulaire et Ingénierie Thérapeutique · FRDirection de la Recherche Fondamentale · FRLaboratory of Fundamental and Applied Bioenergetics · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nevoid basal cell carcinoma syndrome (NBCCS), also called Gorlin syndrome is an autosomal dominant disorder whose incidence is estimated at about 1 per 55,600-256,000 individuals. It is characterized by several developmental abnormalities and an increased predisposition to the development of basal cell carcinomas (BCCs). Cutaneous fibroblasts from Gorlin patients have been shown to exhibit an increased sensitivity to ionizing radiations. Mutations in the tumor suppressor gene

Indexed as

base excision repairDNA repairnevoid basal cell carcinoma syndromePTCH1 mutationROS production

Identifiers

PMID32850458
PMCPMC7427476
OpenAlexW3048321541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.