ArticleAvicenna journal of phytomedicine
Role of the potassium channels in vasorelaxant effect of asafoetida essential oil.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Antiviral activity ofIranian journal of microbiology · 2024Article
- Vasorelaxant and Blood Pressure-Lowering Effects ofInternational journal of molecular sciences · 2024Article
- Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of theFrontiers in pharmacology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn a previous work, we showed that asafoetida essential oil (AEO), from oleo-gum resin of MATERIALS AND
methodsRats' thoracic aorta were isolated and denuded. Following induction of contraction by potassium chloride (60 mM), concentration-response curve was plotted by the cumulative addition of AEO (0.625-80 µl/l to the medium of rings. The vasodilatory effect of AEO was assessed before and after addition of phenylephrine and potassium channel blockers (including barium chloride (BC), 4-aminopyridine (4A) and glibenclamide (Gl)).
resultsAEO relaxed the precontracted rings in a concentration-dependent manner (IC50=23 µl/l). All potassium channel blockers significantly attenuated the vasodilatory activity of AEO when they were added to rings medium before addition of KCl (p<0.01, 4A and Gl groups and p< 0.001, BC group vs. control group) but not after that. In contrast to K channel blockers, adding AEO before or after phenylephrine, the tension was reduced significantly (p<0.05 vs. the control group).
conclusionThe findings of this study indicated that the vasodilatory effect of AEO on denuded-endothelium aortic ring was mediated through activation of potassium channels and reduced intracellular calcium release.
Indexed as
Identifiers
32850297PMC7430957W3007845262What OpenQuestion holds
Registered trials
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