ArticleOxidative medicine and cellular longevity2020
Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-
Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 7 of them syntheses that pooled it.
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Who cites it
99 citing papers in PubMed, 7 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Global research hotspots and trends of acupuncture regulating neuroplasticity: a bibliometric analysis from 2005 to 2024.Frontiers in neurology · 2025Pooled it
- A bibliometric analysis of research on cognitive function and carotid atherosclerosis: global trends and hotspots.Frontiers in neurology · 2025Pooled it
- Neuroimaging evidence of acupuncture in cognitive impairment following ischemic stroke: a systematic review.Frontiers in neuroscience · 2025Pooled it
- The efficacy of acupuncture and related treatments on chronic pelvic inflammatory disease: a network meta-analysis.Frontiers in medicine · 2025Pooled it
- Comparative efficacy and safety of non-pharmacological interventions as adjunctive treatment for vascular dementia: a systematic review and network meta-analysis.Frontiers in neurology · 2024Pooled it
- A network meta-analysis on the improvement of cognition in patients with vascular dementia by different acupuncture therapies.Frontiers in neuroscience · 2022Pooled it
- Efficacy of acupuncture in animal models of vascular dementia: A systematic review and network meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Targeting NF-κB/TLR4/ERK/MYD88 and Caspase-1/IL-1β Pathways by Diacerein in Alleviation of 5-Fluorouracil-Induced Myocardial, Corneal, and Retinal Injury.Cardiovascular toxicology · 2026Article
- Curcumin relieves gas explosion-induced brain injury via TLR4-mediated M2 polarization of microglia.Brain, behavior, & immunity - health · 2026Article
- Advances in electroacupuncture for perioperative neurocognitive disorders: mechanisms and clinical evidence.Chinese medicine · 2026Review
- Gene Therapy for Cardiovascular and Cerebrovascular Disease: Mechanisms, Translational Barriers, and the Road Ahead.Biomedicines · 2026Review
- Targeting glial-orchestrated neuroinflammation in migraine pathophysiology.The journal of headache and pain · 2026Review
- Rewiring brain structural and functional disconnection with acupuncture in rat model of vascular cognitive impairment and dementia.Biological research · 2026Article
- Acupuncture for Post-Stroke Cognitive Impairment: Mechanisms and Clinical Evidence (2020-2025).Neuropsychiatric disease and treatment · 2026Review
- Acupuncture's Regulatory Role in Glial Cells and Their Interactions for Antidepressant Effects: A Review of Research Progress.Journal of multidisciplinary healthcare · 2026Review
- Identification and Analysis of Remimazolam's Potential Therapeutic Mechanisms in Murine Sepsis-Associated Encephalopathy via Transcriptomic Analysis.Journal of inflammation research · 2026Article
- Effect of warm reinforcing acupuncture combined with whole-body vibration training on knee joint function and inflammatory factors in stroke patients with knee osteoarthritis.American journal of translational research · 2026Article
- Therapeutic Potential ofLife (Basel, Switzerland) · 2025Review
- Umbilical cord blood-derived exosomes deliver miR-182-5p to Therapeutically target the MYD88/NF-κB signaling pathway in rat peri-implantitis.Materials today. Bio · 2025Article
- Mechanism analysis of Tongqiao Yizhi decoction in treating vascular dementia rats by brain tissue untargeted metabonomics and fecal 16S rRNA gene sequencing.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is widely accepted that inflammation may contribute to cognitive impairment in patients with vascular dementia (VD). Our prior clinical researches have reported that acupuncture can alleviate cognitive function in VD, but the underlying mechanisms are still unclear. The purpose of this research was to explore whether acupuncture alleviates cognitive impairment by suppressing the microRNA-93- (miR-93-) mediated Toll-like receptor (TLR) signaling pathway, which triggers inflammatory responses in the central nervous system.
methodsVD was established by permanent bilateral common carotid artery occlusion in male Wistar rats. Three days after operation, the rats began daily treatment with acupuncture for two weeks. The levels of miR-93, Toll-like receptors (TLR2 and TLR4), intracellular signaling molecules (myeloid differentiation factor 88 (MyD88) and nuclear factor-kappa B (NF-
resultsWe found that acupuncture notably repressed the expression of inflammatory cytokines in the hippocampus and plasma of VD rats. The expression of TLR4, but not TLR2, was markedly downregulated by acupuncture, accompanied by a decrease in miR-93 and MyD88/NF-
conclusionsTaken together, these findings provide evidence that acupuncture attenuates cognitive impairment associated with inflammation through inhibition of the miR-93-mediated TLR4/MyD88/NF-
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.