Evidence map›Paper›PMID 32849868›Full record

ArticleGastroenterology research and practice2020

Small-Bowel Lesions in Patients Taking Direct Oral Anticoagulants Detected Using Capsule Endoscopy.

Minoru Yamaoka, Hiroyuki Imaeda, Naoki Hosoe, Kazuaki Yoneno, Ryu Kanno, Takashi Mitsufuji, Takahiro Sasaki, Yuji Akiyama, Hideki Ohgo, Yuichi Morohoshi and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology research and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Minoru YamaokaDepartment of General Internal Medicine, Saitama Medical University, Japan.
Hiroyuki ImaedaDepartment of General Internal Medicine, Saitama Medical University, Japan.ORCID https://orcid.org/0000-0003-0898-6540
Naoki HosoeCenter for Diagnostic and Therapeutic Endoscopy, Keio University, Japan.
Kazuaki YonenoDepartment of Gastroenterology, Saitama Medical Center, Japan.
Ryu KannoDepartment of General Internal Medicine, Saitama Medical University, Japan.
Takashi MitsufujiDepartment of Neurology, Saitama Medical University, Japan.
Takahiro SasakiDepartment of Neurology, Saitama Medical University, Japan.
Yuji AkiyamaDepartment of Rheumatology, Saitama Medical University, Japan.
Hideki OhgoDepartment of General Internal Medicine, Saitama Medical University, Japan.
Yuichi MorohoshiDepartment of Gastroenterology, Yokohama Municipal Citizen's Hospital, Japan.
Takanori KanaiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Japan.
Toshimasa YamamotoDepartment of Neurology, Saitama Medical University, Japan.
Toshihide MimuraDepartment of Rheumatology, Saitama Medical University, Japan.ORCID https://orcid.org/0000-0002-9050-0855
Haruhiko OgataCenter for Diagnostic and Therapeutic Endoscopy, Keio University, Japan.
Nobuo ArakiDepartment of Neurology, Saitama Medical University, Japan.
Keiji YamamotoDepartment of Cardiology, Saitama Medical University, Japan.
Hidetomo NakamotoDepartment of General Internal Medicine, Saitama Medical University, Japan.
Saitama Medical University · JPKeio University · JPSocial Insurance Saitama Chuo Hospital · JPYokohama Municipal Citizen's Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

methodsThis study was a prospective, open-label, nonblinded, multicenter, and observational study. From September 2013 to March 2017, patients taking DOACs were enrolled. Patients underwent VCE. The type and location of small-bowel lesions were registered. Also, (1) the proportion of lesions detected between types of DOAC was evaluated and (2) the hemoglobin (Hb) and serum ferritin levels were compared between patients with and without small-bowel lesions.

results33 patients were enrolled, but 4 patients withdrew their consent, and VCE was performed on 29 patients. Eight, 13, and 8 patients received dabigatran, rivaroxaban, and apixaban, respectively. Small-bowel transit was complete in 27 of 29 patients (93.1%). Small-bowel lesions were detected in 23 (79.3%), redness in 12 (41.4%), erosions in 14 (48.3%), and angioectasia in 3 (10.3%) patients, and 6 patients (20.7%) had no abnormalities. Redness and erosions were detected in the upper, middle, or lower portions, but erosions tended to be less frequent in the middle portion (

conclusionMany patients taking DOACs had small-bowel lesions; however, most lesions were relatively mild. Observing small-bowel lesions over longer periods may be necessary in patients taking DOACs. This trial is registered with UMIN000011527.

Identifiers

PMID32849868
PMCPMC7439185
OpenAlexW3048368196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.