Evidence map›Paper›PMID 32849657›Full record

ArticleFrontiers in immunology2020

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.

Sofie H Møller, Maiken Mellergaard, Mikkel Madsen, Amaia V Bermejo, Stine D Jepsen, Marie H Hansen, Rikke I Høgh, Blanca I Aldana, Claus Desler, Lene Juel Rasmussen and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 3 countries.

Sofie H MøllerDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Maiken MellergaardDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Mikkel MadsenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Amaia V BermejoDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Stine D JepsenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Marie H HansenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Rikke I HøghDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Blanca I AldanaDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Claus DeslerCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Lene Juel RasmussenCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Elahu G SustarsicNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Zachary Gerhart-HinesNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Evangelia DaskalakiDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Craig E WheelockDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Thomas K HironWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Da LinWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Christopher A O'CallaghanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Hans H WandallCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Lars AndresenDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Søren SkovDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
University of Copenhagen · DKCentre for Human Genetics · GBKarolinska Institutet · SENovo Nordisk Foundation · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune surveillance of cancer cells is facilitated by the Natural Killer Group 2D (NKG2D) receptor expressed by different lymphocyte subsets. It recognizes NKG2D ligands that are rarely expressed on healthy cells, but upregulated by tumorigenesis, presenting a target for immunological clearance. The molecular mechanisms responsible for NKG2D ligand regulation remain complex. Here we report that cancer cell metabolism supports constitutive surface expression of the NKG2D ligand MHC class I chain-related proteins A (MICA). Knockout of the

Indexed as

ImmunomodulationCell Line, TumorChromatin Assembly and DisassemblyCitric AcidCytoplasmFemaleGene EditingGene Expression RegulationGlycolysisHEK293 CellsHistocompatibility Antigens Class IHumansLigandsLymphocyte ActivationLymphocytesMitochondriaCitric AcidHistocompatibility Antigens Class ILigandsMgat5 protein, humanMHC class I-related chain AN-AcetylglucosaminyltransferasesNK Cell Lectin-Like Receptor Subfamily KATP citrate lyasecancer metabolismcitrateMHC class I chain-related proteins ANatural Killer Group 2Dtumor immunology

Identifiers

PMID32849657
PMCPMC7431954
OpenAlexW3048411456

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.