Evidence map›Paper›PMID 32849636›Full record

ArticleFrontiers in immunology2020

Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis.

Nicolas S Merle, Juliette Leon, Victoria Poillerat, Anne Grunenwald, Idris Boudhabhay, Samantha Knockaert, Tania Robe-Rybkine, Carine Torset, Matthew C Pickering, Sophie Chauvet and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Complement: The Road Less Traveled.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  5. Review
  6. Heme Oxygenase 1: A Defensive Mediator in Kidney Diseases.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Nicolas S MerleCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Juliette LeonCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Victoria PoilleratCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Anne GrunenwaldCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Idris BoudhabhayCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Samantha KnockaertCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Tania Robe-RybkineCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Carine TorsetCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Matthew C PickeringCentre for Complement and Inflammation Research, Imperial College London, London, United Kingdom.
Sophie ChauvetCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Veronique Fremeaux-BacchiCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Lubka T RoumeninaCentre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.
Centre de Recherche des Cordeliers · FRSorbonne Université · FRUniversité Paris Cité · FRHôpital Européen Georges-Pompidou · FRImperial College London · GBInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intravascular hemolysis of any cause can induce acute kidney injury (AKI). Hemolysis-derived product heme activates the innate immune complement system and contributes to renal damage. Therefore, we explored the role of the master complement regulator Factor H (FH) in the kidney's resistance to hemolysis-mediated AKI. Acute systemic hemolysis was induced in mice lacking liver expression of FH (hepatoFH

Indexed as

Complement ActivationHemolysisAnimalsComplement C5aComplement Factor HDisease Models, AnimalGene Expression RegulationHepatocytesKidney GlomerulusKidney Tubular Necrosis, AcuteKidney TubulesMice, Inbred C57BLMice, KnockoutPhenylhydrazinesReceptor, Anaphylatoxin C5aSignal TransductionC5ar1 protein, mouseComplement C5aComplement Factor HphenylhydrazinePhenylhydrazinesReceptor, Anaphylatoxin C5aacute tubular damagecomplement factor Hcomplement – immunological termhemolysiskidney

Identifiers

PMID32849636
PMCPMC7426730
OpenAlexW3047195458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.