Evidence map›Paper›PMID 32849551›Full record

ArticleFrontiers in immunology2020

The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.

Henrik Einwächter, Alexander Heiseke, Andreas Schlitzer, Georg Gasteiger, Heiko Adler, David Voehringer, Markus G Manz, Zsolt Ruzsics, Lars Dölken, Ulrich H Koszinowski and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. CD71Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 2 countries.

Henrik EinwächterII. Medizinische Klinik, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Alexander HeisekeII. Medizinische Klinik, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Andreas SchlitzerLIMES-Institute Bonn, Bonn, Germany.
Georg GasteigerInstitute of Systems Immunology, Julius-Maximilians-University Würzburg, Würzburg, Germany.
Heiko AdlerComprehensive Pneumology Center, Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Munich, Germany.
David VoehringerDepartment of Infection Biology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Nürnberg, Erlangen, Germany.
Markus G ManzDivision of Hematology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland.
Zsolt RuzsicsInstitute of Virology, University Medical Center, Medical Faculty, University of Freiburg, Freiburg, Germany.
Lars DölkenInstitute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Würzburg, Germany.
Ulrich H KoszinowskiMax von Pettenkofer-Institute, Ludwig-Maximilians-Universität München, Munich, Germany.
Tim SparwasserInstitute of Medical Microbiology and Hygiene, University Medicine Mainz, Johannes-Gutenberg-University Mainz, Mainz, Germany.
Wolfgang ReindlII. Medizinische Klinik, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany.
Stefan JordanCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Microbiology, Infectious Diseases and Immunology, Berlin, Germany.
University of Würzburg · DEFreie Universität Berlin · DEGerman Center for Lung Research · DEHeidelberg University · DEKlinikum rechts der Isar · DELudwig-Maximilians-Universität München · DETechnical University of Munich · DEUniversitätsklinikum Erlangen · DEUniversity Hospital of Zurich · CHUniversity Medical Center Freiburg · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DC) play a key role in the adaptive immune response due to their ability to present antigens and stimulate naïve T cells. Many bacteria and viruses can efficiently target DC, resulting in impairment of their immunostimulatory function or elimination. Hence, the DC compartment requires replenishment following infection to ensure continued operational readiness of the adaptive immune system. Here, we investigated the molecular and cellular mechanisms of inflammation-induced DC generation. We found that infection with viral and bacterial pathogens as well as Toll-like receptor 9 (TLR9) ligation with CpG-oligodeoxynucleotide (CpG-ODN) expanded an erythropoietin (EPO)-dependent TER119

Indexed as

Immunity, InnateAnimalsBiomarkersBlood Group AntigensCD11c AntigenCell DifferentiationCytokinesDendritic CellsDisease Models, AnimalErythropoietinFemaleHematopoiesis, ExtramedullaryImmunophenotypingInfectionsInflammationMiceBiomarkersBlood Group AntigensCD11c AntigenCPG-oligonucleotideCytokinesErythropoietinOligodeoxyribonucleotidesTER-119 antigen, mousedendritic cellerythropoietinextramedullary hematopoiesisinfectioninflammationTER119toll-like receptor

Identifiers

PMID32849551
PMCPMC7411349
OpenAlexW3046776918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.