Evidence map›Paper›PMID 32849547›Full record

ArticleFrontiers in immunology2020

Hematopoietic Cell Transplantation for Chronic Granulomatous Disease in Japan.

Masakatsu Yanagimachi, Koji Kato, Akihiro Iguchi, Koji Sasaki, Chikako Kiyotani, Katsuyoshi Koh, Takashi Koike, Hideki Sano, Tomonari Shigemura, Hideki Muramatsu and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 16 institutions in 1 country.

Masakatsu YanagimachiDepartment of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan.
Koji KatoDepartment of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.
Akihiro IguchiDepartment of Pediatrics, Hokkaido University Hospital, Sapporo, Japan.
Koji SasakiDepartment of Pediatrics, Yokohama City University, Yokohama, Japan.
Chikako KiyotaniChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Katsuyoshi KohDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Takashi KoikeDepartment of Pediatrics, Tokai University School of Medicine, Isehara, Japan.
Hideki SanoDepartment of Pediatric Oncology, Fukushima Medical University Hospital, Fukushima, Japan.
Tomonari ShigemuraDepartment of Pediatrics, Shinshu University School of Medicine, Nagano, Japan.
Hideki MuramatsuDepartment of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Keiko OkadaDepartment of Pediatric Hematology/Oncology, Osaka City General Hospital, Osaka, Japan.
Masami InoueDepartment of Pediatric Hematology/Oncology, Osaka Women's and Children's Hospital, Osaka, Japan.
Ken TabuchiDivision of Pediatrics, Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital, Tokyo, Japan.
Toyoki NishimuraDivision of Pediatrics, Developmental and Urological-Reproductive Medicine Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Tomoyuki MizukamiDivision of Pediatrics, Developmental and Urological-Reproductive Medicine Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Hiroyuki NunoiDivision of Pediatrics, Developmental and Urological-Reproductive Medicine Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kohsuke ImaiDepartment of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan.
Masao KobayashiDepartment of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan.
Tomohiro MorioDepartment of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan.
Tokyo Medical and Dental University · JPUniversity of Miyazaki · JPFukushima Medical University Hospital · JPHiroshima University · JPHokkaido University Hospital · JPKanagawa Children's Medical Center · JPKumamoto Medical Center · JPNagoya University · JPNational Center For Child Health and Development · JPOsaka City General Hospital · JPOsaka Women's and Children's Hospital · JPSaitama Children's Medical Center · JPShinshu University · JPTokai University · JPTokyo Metropolitan Komagome Hospital · JPYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hematopoietic cell transplantation (HCT) is established as a curative treatment for severe chronic granulomatous disease (CGD). However, outcomes of HCT for CGD in Japan had not been precisely reported. We evaluated the outcome of HCT for CGD in Japan by means of a nationwide survey. A total of 91 patients (86 males and 5 females) with CGD who received HCT between 1992 and 2013 was investigated. Their median age at HCT was 11 years (0-39). Sixty-four patients had X-linked CGD caused by CYBB gene mutations, 13 had autosomal recessive CGD (7 CYBA and 6 NCF2), and 14 were genetically undetermined. Seventy patients are still alive at a median follow-up of 38.9 (3.7-230) months. Three-year OS and EFS was 73.7 and 67.6%, respectively. Twenty-one patients died mainly from transplant-related mortality. The cumulative incidence of grade II to IV acute GVHD and extensive chronic GVHD was 27.2 and 17.9%, respectively. Risk factors for EFS after HCT for CGD were age >30 years (

Indexed as

Hematopoietic Stem Cell TransplantationAdolescentAdultChildChild, PreschoolDisease SusceptibilityFemaleGenetic Predisposition to DiseaseGraft vs Host DiseaseGranulomatous Disease, ChronicHistocompatibility TestingHumansInfantInfant, NewbornJapanKaplan-Meier EstimateCYBB protein, humanNADPH Oxidase 2adultchronic granulomatous diseasecord blood transplantationCYBBhematopoietic cell transplantationlow-dose irradiation

Identifiers

PMID32849547
PMCPMC7403177
OpenAlexW3046051443

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.