Evidence map›Paper›PMID 32849520›Full record

ArticleFrontiers in immunology2020

Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis.

Jingjing Feng, Siyuan Fan, Yinwei Sun, Zhidong Zhang, Haitao Ren, Wenhan Li, Liying Cui, Bin Peng, Xiaotun Ren, Weihua Zhang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Jingjing FengCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
Siyuan FanDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yinwei SunCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
Zhidong ZhangOumeng V Medical Laboratory, Hangzhou, China.
Haitao RenDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wenhan LiOumeng V Medical Laboratory, Hangzhou, China.
Liying CuiDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Bin PengDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xiaotun RenDepartment of Neurology, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
Weihua ZhangDepartment of Neurology, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
Hongzhi GuanDepartment of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jing WangCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing Children’s Hospital · CNUniversity of Chinese Academy of Sciences · CNInstitute of Psychology, Chinese Academy of Sciences · CNPeking Union Medical College Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common antibody-mediated encephalitis. There are several studies on B cell repertoire of anti-NMDAR encephalitis in Caucasians. Here, the cerebrospinal fluid (CSF) samples of 12 Chinese patients with first-episode anti-NMDAR encephalitis were collected to investigate the B cell receptor (BCR) binding to NMDAR by single cell amplification of BCR and Sanger sequencing. BCR data of healthy persons, and of patients with anti-leucine-rich glioma inactivated 1 (anti-LGI1) encephalitis, multiple sclerosis (MS), and neuromyelitis optica spectrum disorder (NMOSD) from the public databases were used as control. A heavy chain common clone IGHV1-18

Indexed as

Disease SusceptibilityAdolescentAdultAnti-N-Methyl-D-Aspartate Receptor EncephalitisAutoantibodiesBiomarkersB-LymphocytesChildChild, PreschoolClonal EvolutionComputational BiologyDisease ManagementFemaleHigh-Throughput Nucleotide SequencingHumansImmunophenotypingAutoantibodiesBiomarkersReceptors, Antigen, B-Cellanti-NMDAR encephalitisB cell repertoirecommon clonediagnosissingle cell

Identifiers

PMID32849520
PMCPMC7403192
OpenAlexW3045666514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.