ArticleFrontiers in microbiology2020
High-Fat Diet Affects Heavy Metal Accumulation and Toxicity to Mice Liver and Kidney Probably via Gut Microbiota.
Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach.Journal of health, population, and nutrition · 2025Pooled it
- High-Dietary Fiber Diet Reduces Arsenic Oral Bioavailability and Health Risk from Soils by Regulating Gut Microbiota and Intestinal Barrier Function.Foods (Basel, Switzerland) · 2026Article
- Chronic heavy metal exposure in Yunnan Province disrupts intestinal defenses and increases susceptibility to pathogens: an integrative review.Frontiers in public health · 2026Review
- Dynamics of Gut Microbiota in Japanese Tits (Microorganisms · 2025Article
- Mediation and moderation by inflammation and dietary patterns in heavy metal exposure effects on kidney function.Scientific reports · 2025Article
- Astaxanthin Alleviates Lead-Induced Toxicity by Restoring Hepatic and Gut-Liver Axis Homeostasis Through Multidimensional Metabolic and Antioxidative Pathways.Food science & nutrition · 2025Article
- Study on the pathogenesis of idiopathic pediatric acute pancreatitis by combining intestinal microbiome and metabolome.Translational pediatrics · 2025Article
- Associations of a metal mixture and vitamin D with sleep duration among adolescents and young adults from the 2011-2018 NHANES cycles.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025Article
- Environmental Cadmium Exposure Exacerbated Bone Loss in NAFLD Mice.Biological trace element research · 2024Article
- Alleviation of Lipid Disorder and Liver Damage in High-Fat Diet-Induced Obese Mice by Selenium-EnrichedNutrients · 2024Article
- Breast Cancer Exposomics.Life (Basel, Switzerland) · 2024Review
- Influence of heavy metal exposure on gut microbiota: Recent advances.Journal of biochemical and molecular toxicology · 2023Review
- Matrine Protects Intestinal Barrier Function via MicroRNA-155 Through ROCK1-Signaling Pathway.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Nutraceuticals as Alternative Approach against Cadmium-Induced Kidney Damage: A Narrative Review.Metabolites · 2023Review
- Intestinal bacteria diversity of suckermouth catfish (Heliyon · 2023Article
- Lead exposure exacerbates adverse effects of HFD on metabolic function via disruption of gut microbiome, leading to compromised barrier function and inflammation.European journal of nutrition · 2023Article
- Threonine Facilitates Cd Excretion by Increasing the Abundance of GutMolecules (Basel, Switzerland) · 2022Article
- Impact of Heavy Metal Toxicity on the Gut Microbiota and Its Relationship with Metabolites and Future Probiotics Strategy: a Review.Biological trace element research · 2022Review
- Oleic Acid Facilitates Cd Excretion by Increasing the Abundance ofInternational journal of molecular sciences · 2022Article
- Linking the gut microbiome to microglial activation in opioid use disorder.Frontiers in neuroscience · 2022Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies proved that heavy metals could increase the risk of disease by acting on the gut microbiota. Meanwhile, gut microbiota played important roles in detoxifying heavy metals. However, the response of gut microbiota to heavy metals and which microbes dominated this detoxification processes are still unclear. This study investigated the difference of high-fat-diet (HFD) and normal-diet (ND) gut microbiota and their response to and detoxification effects on arsenic (As), cadmium (Cd), and lead (Pb) exposure. Results showed that gut microbiota of ND and HFD was significantly different and responded to As, Pb, and Cd exposure differently, too. When exposed to 100 ppm As, Cd, or Pb, HFD-fed mice accumulated more heavy metals in the liver and kidney along with more severe functional damage than ND-fed mice, indicated by a more dramatic increase of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities and urinary total protein (TPU), urinary uric acid (UUA), and urinary creatinine (Ucrea) content. Among ND gut microbiota, relative abundance of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.