ReviewFrontiers in neurology2020
Circadian Disruption in Critical Illness.
Review in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07063303 (The Effect of Intermittent Feeding on Circadian Rhythm in Critical Illness), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Intermittent Feeding on Circadian Rhythm in Critical Illness
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Digital sleep phenotype and wrist actigraphy in individuals at clinical high risk for psychosis and people with schizophrenia spectrum disorders: a systematic review and meta-analysis.BMJ mental health · 2025Pooled it
- Predicting Adverse ICU Outcomes from Admission-Time Frailty and Nocturnal Sleep Fragmentation Using Explainable AI.Journal of clinical medicine · 2026Article
- Loss of daily phase relations identified by multiomic analyses in acute pancreatitis.Biochemistry and biophysics reports · 2026Article
- Psychosocial outcome of COVID-19 patients requiring ventilation after ECMO versus long-term mechanical ventilation.Frontiers in cardiovascular medicine · 2026Article
- Chrononutrition in Critical Illness.Nutrition reviews · 2025Review
- A randomized controlled trial examining the impact of diversified nursing interventions on the circadian rhythm of sedated critically ill patients.Frontiers in medicine · 2025Article
- Disrupted Circadian Rhythms and Substance Use Disorders: A Narrative Review.Clocks & sleep · 2024Review
- Volume-based subglottic secretion drainage: a randomized controlled trial.Annals of medicine and surgery (2012) · 2024Article
- The Physiological and Pharmacological Significance of the Circadian Timing of the HPA Axis: A Mathematical Modeling Approach.Journal of pharmaceutical sciences · 2024Review
- Enhancing circadian rhythms-the circadian MEGA bundle as novel approach to treat critical illness.Annals of translational medicine · 2023Review
- Circadian rhythm disturbance and delirium in ICU patients: a prospective cohort study.BMC anesthesiology · 2023Article
- The role of the circadian rhythms in critical illness with a focus on acute pancreatitis.Heliyon · 2023Review
- Noise reduction in the ICU: a best practice implementation project.JBI evidence implementation · 2022Article
- Circadian rest-activity misalignment in critically ill medical intensive care unit patients.Journal of sleep research · 2022Article
- Sleep Assessment in Critically Ill Adults: Established Methods and Emerging Strategies.Critical care explorations · 2022Review
- Multi-tissue transcriptional changes and core circadian clock disruption following intensive care.Frontiers in physiology · 2022Article
- Circadian Effects of Drug Responses.Annual review of biomedical engineering · 2021Article
- Is there a role for melatonin in the ICU?The Southern African journal of critical care : the official journal of the Critical Care Society · 2021Review
- Noise Pollution in Intensive Care Unit: A Hidden Enemy affecting the Physical and Mental Health of Patients and Caregivers.Noise & healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Circadian rhythms play a vital role in metabolic, hormonal, and immunologic function and are often disrupted in patients in the ICU. Circadian rhythms modulate the molecular machinery that responds to injury and illness which can impact recovery. Potential factors contributing to the alteration in circadian rhythmicity in intensive care unit (ICU) patients include abnormal lighting, noise, altered feeding schedules, extensive patient care interactions and medications. These alterations in circadian rhythms in ICU patients may affect outcomes and therefore, normalization of circadian rhythmicity in critically ill patients may be an important part of ICU care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.