ReviewFrontiers in neurology2020
Modern Brainstem MRI Techniques for the Diagnosis of Parkinson's Disease and Parkinsonisms.
Review in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Biological heterogeneity in Parkinson's disease: implications for MRI-based patient stratification.NPJ Parkinson's disease · 2026Review
- The role of neuro-imaging in multiple system atrophy.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Ultraviolet radiation and neurodegeneration: molecular mechanisms underlying dual neuroprotective and neurotoxic effects.Frontiers in cellular neuroscience · 2026Review
- Central Pathophysiology and Brain Network Changes Related to Camptocormia in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Review
- Imaging advances to detect non-motor prodromal markers of Parkinson's disease and explore therapeutic translation opportunities.NPJ Parkinson's disease · 2025Review
- Structural Alterations Associated With Cardiovascular Autonomic Failure in Multiple System Atrophy.European journal of neurology · 2025Article
- Advanced Immunolabeling Method for Optical Volumetric Imaging Reveals Dystrophic Neurites of Dopaminergic Neurons in Alzheimer's Disease Mouse Brain.Molecular neurobiology · 2024Article
- Exploiting macro- and micro-structural brain changes for improved Parkinson's disease classification from MRI data.NPJ Parkinson's disease · 2024Article
- Neuromelanin-sensitive MRI as a promising biomarker of catecholamine function.Brain : a journal of neurology · 2024Review
- Neuroinflammation and Mitochondrial Dysfunction in Parkinson's Disease: Connecting Neuroimaging with Pathophysiology.Antioxidants (Basel, Switzerland) · 2023Review
- Structural alterations of spinocerebellar ataxias type 3: from pre-symptomatic to symptomatic stage.European radiology · 2023Article
- Relevance ofEJNMMI research · 2023Article
- Diffusion Magnetic Resonance Imaging Microstructural Abnormalities in Multiple System Atrophy: A Comprehensive Review.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Morphometric imaging and quantitative susceptibility mapping as complementary tools in the diagnosis of parkinsonisms.European journal of neurology · 2022Article
- Multiple system atrophy.Nature reviews. Disease primers · 2022Review
- Comparative morphometric evaluation of the brainstem in neurodegenerative diseases with healthy individuals using magnetic resonance imaging.Journal of Taibah University Medical Sciences · 2022Article
- Combined regional T1w/T2w ratio and voxel-based morphometry in multiple system atrophy: A follow-up study.Frontiers in neurology · 2022Article
- Improving Imaging of the Brainstem and Cerebellum in Autistic Children: Transformation-Based High-Resolution Diffusion MRI (TiDi-Fused) in the Human Brainstem.Frontiers in integrative neuroscience · 2022Article
- Imaging of Substantia Nigra in Parkinson's Disease: A Narrative Review.Brain sciences · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brainstem is the earliest vulnerable structure in many neurodegenerative diseases like in Multiple System Atrophy (MSA) or Parkinson's disease (PD). Up-to-now, MRI studies have mainly focused on whole-brain data acquisition. Due to its spatial localization, size, and tissue characteristics, brainstem poses particular challenges for MRI. We provide a brief overview on recent advances in brainstem-related MRI markers in Parkinson's disease and Parkinsonism's. Several MRI techniques investigating brainstem, mainly the midbrain, showed to be able to discriminate PD patients from controls or to discriminate PD patients from atypical parkinsonism patients: iron-sensitive MRI, nigrosome imaging, neuromelanin-sensitive MRI, diffusion tensor imaging and advanced diffusion imaging. A standardized multimodal brainstem-dedicated MRI approach at high resolution able to quantify microstructural modification in brainstem nuclei would be a promising tool to detect early changes in parkinsonian syndromes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.