ArticleFrontiers in psychology2020
Bringing the Laboratory Home: PANDABox Telehealth-Based Assessment of Neurodevelopmental Risk in Children.
Article in Frontiers in psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Use of Wearable Sensors in Angelman Syndrome: A Systematic Review.Journal of intellectual disability research : JIDR · 2026Pooled it
- Telehealth and healthcare access for individuals with Down syndrome: a systematic review of opportunities and barriers.BMC health services research · 2026Pooled it
- Tablet Assessment of Cognition in Down Syndrome: Comparison of Researcher and Caregiver Administration.Journal of intellectual disability research : JIDR · 2026Article
- Performance and Biases of the LENA and ACLEW Algorithms in Analyzing Language Environments in Down, Fragile X, Angelman Syndromes, and Populations at Elevated Likelihood for Autism.Developmental science · 2026Article
- Experiences of Spanish-Speaking Families with a Remote Neurodevelopmental Assessment.Journal of autism and developmental disorders · 2026Article
- Prelinguistic Communication Complexity of Children With Neurogenetic Syndromes.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Measuring Patient-Reported Acceptability Outcomes via the Program Acceptability Tool for Telehealth.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2025Article
- Remote EEG acquisition in Angelman syndrome using PANDABox-EEG.Journal of neurodevelopmental disorders · 2025Article
- Remote monitoring of social attention in neurogenetic syndromes and idiopathic neurodevelopmental disability.Autism research : official journal of the International Society for Autism Research · 2025Article
- Employing user-centered design to develop a remote technology kit for studying young children's social communication skills.Journal of pediatric psychology · 2025Article
- Assessment of Autism Spectrum Disorder.Assessment · 2024Review
- Exploring the feasibility of collecting multimodal multiperson assessment data via distance in families affected by fragile X syndrome.Journal of telemedicine and telecare · 2023Article
- Pilot protocol for the Parent and Infant Inter(X)action Intervention (PIXI) feasibility study.PloS one · 2023Article
- Zoom, Zoom, Baby! Assessing Mother-Infant Interaction During the Still Face Paradigm and Infant Language DevelopmentFrontiers in psychology · 2021Article
- Online and Face-to-Face Performance on Two Cognitive Tasks in Children With Williams Syndrome.Frontiers in psychology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAdvances in clinical trials have revealed a pressing need for outcome measures appropriate for children with neurogenetic syndromes (NGS). However, the field lacks a standardized, flexible protocol for collecting laboratory-grade experimental data remotely. To address this challenge, we developed PANDABox (Parent-Administered Neurodevelopmental Assessment), a caregiver-facilitated, remotely administered assessment protocol for collecting integrated and high quality clinical, behavioral, and spectral data relevant to a wide array of research questions. Here, we describe PANDABox development and report preliminary data regarding: (1) logistics and cost, (2) caregiver fidelity and satisfaction, and (3) data quality.
methodsWe administered PANDABox to a cohort of 16 geographically diverse caregivers and their infants with Down syndrome. Tasks assessed attention, language, motor, and atypical behaviors. Behavioral and physiological data were synchronized and coded offline by trained research assistants.
resultsPANDABox required low resources to administer and was well received by families, with high caregiver fidelity (94%) and infant engagement (91%), as well as high caregiver-reported satisfaction (97% positive). Missing data rates were low for video frames (3%) and vocalization recordings (6%) but were higher for heart rate (25% fully missing and 13% partially missing) and discrete behavioral presses (8% technical issues and 19% not enough codable behavior), reflecting the increased technical demands for these activities.
conclusionWith further development, low-cost laboratory-grade research protocols may be remotely administered by caregivers in the family home, opening a new frontier for cost-efficient, scalable assessment studies for children with NGS other neurodevelopmental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.