ArticleFrontiers in human neuroscience2020
Digital Biomarkers for the Early Detection of Mild Cognitive Impairment: Artificial Intelligence Meets Virtual Reality.
Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Leveraging human-robot interaction and virtual reality for digital biomarkers in diagnostics and rehabilitation: a review from the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Pooled it
- Machine learning based algorithms for virtual early detection and screening of neurodegenerative and neurocognitive disorders: a systematic-review.Frontiers in neurology · 2024Pooled it
- Technology-Assisted Cognitive Motor Dual-Task Rehabilitation in Chronic Age-Related Conditions: Systematic Review.Journal of medical Internet research · 2023Pooled it
- Psilocybin therapy for treatment resistant depression: prediction of clinical outcome by natural language processing.Psychopharmacology · 2025Trial
- VRrec: A zero-coding open-source VR body-motion capture tool for behavioral research.Behavior research methods · 2026Article
- The Use of Patient-Reported Outcome Measures in Developmental Age: A Complementary Tool for Pediatric Multiple Sclerosis Prognosis.Neurology and therapy · 2026Review
- More than Just a Game: A Longitudinal Pilot Study on the Outcome Effects of Home-Based Digital Cognitive Rehabilitation in Outpatients with Mild Cognitive Impairment.Brain sciences · 2026Article
- Artificial Intelligence for the Early Detection of Patients with Cognitive Impairment: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Editorial: Machine learning-driven insights into cognitive aging and behavioral changes.Frontiers in aging · 2026Article
- Graphomotor performance as a quantitative marker of Alzheimer's disease: a tablet-based case-control ROC study.Frontiers in neuroscience · 2026Article
- Automated MoCA scoring for Arabic speakers using hybrid AI of multimodal speech, vision, and LLM integration.Frontiers in psychology · 2026Article
- Aging well in an aging society: Italy at the forefront of global aging and the Age-It Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Digital Twin Cognition: AI-Biomarker Integration in Biomimetic Neuropsychology.Biomimetics (Basel, Switzerland) · 2025Review
- Alzheimer's disease digital biomarkers multidimensional landscape and AI model scoping review.NPJ digital medicine · 2025Article
- Neurotechnological Approaches to Cognitive Rehabilitation in Mild Cognitive Impairment: A Systematic Review of Neuromodulation, EEG, Virtual Reality, and Emerging AI Applications.Brain sciences · 2025Review
- Exploring How Older Adults Experience semAPP, a 360° Media-Based Tool for Memory Assessment: Qualitative Study.JMIR aging · 2024Article
- The Potential of Automated Assessment of Cognitive Function Using Non-Neuroimaging Data: A Systematic Review.Journal of clinical medicine · 2024Review
- Validation and comparison of virtual reality and 3D mobile games for cognitive assessment against ACE-III in 82 young participants.Scientific reports · 2024Article
- Mapping Knowledge Landscapes and Emerging Trends in AI for Dementia Biomarkers: Bibliometric and Visualization Analysis.Journal of medical Internet research · 2024Article
- Integrating Biomarkers From Virtual Reality and Magnetic Resonance Imaging for the Early Detection of Mild Cognitive Impairment Using a Multimodal Learning Approach: Validation Study.Journal of medical Internet research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elderly people affected by Mild Cognitive Impairment (MCI) usually report a perceived decline in cognitive functions that deeply impacts their quality of life. This subtle waning, although it cannot be diagnosable as dementia, is noted by caregivers on the basis of their relative's behaviors. Crucially, if this condition is also not detected in time by clinicians, it can easily turn into dementia. Thus, early detection of MCI is strongly needed. Classical neuropsychological measures - underlying a categorical model of diagnosis - could be integrated with a dimensional assessment approach involving Virtual Reality (VR) and Artificial Intelligence (AI). VR can be used to create highly ecologically controlled simulations resembling the daily life contexts in which patients' daily instrumental activities (IADL) usually take place. Clinicians can record patients' kinematics, particularly gait, while performing IADL (Digital Biomarkers). Then, Artificial Intelligence employs Machine Learning (ML) to analyze them in combination with clinical and neuropsychological data. This integrated computational approach would enable the creation of a predictive model to identify specific patterns of cognitive and motor impairment in MCI. Therefore, this new dimensional cognitive-behavioral assessment would reveal elderly people's neural alterations and impaired cognitive functions, typical of MCI and dementia, even in early stages for more time-sensitive interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.