ArticleFrontiers in neural circuits2020
An Attempt at a Unified Theory of the Neocortical Microcircuit in Sensory Cortex.
Article in Frontiers in neural circuits, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Metabolic Brain Disorders: Prodromes, Symptoms, and Syndromes.International journal of molecular sciences · 2026Review
- Neocortical neurogenesis: a proneural gene perspective.The FEBS journal · 2025Review
- Phase slips extracted from derivatives of EEG data provide a deeper insight into the formation of cortical phase transitions.Frontiers in integrative neuroscience · 2025Article
- A mechanism for deviance detection and contextual routing in the thalamus: a review and theoretical proposal.Frontiers in neuroscience · 2024Article
- An operating principle of the cerebral cortex, and a cellular mechanism for attentional trial-and-error pattern learning and useful classification extraction.Frontiers in neural circuits · 2024Article
- Could theropod dinosaurs have evolved to a human level of intelligence?The Journal of comparative neurology · 2023Review
- Five Breakthroughs: A First Approximation of Brain Evolution From Early Bilaterians to Humans.Frontiers in neuroanatomy · 2021Article
- The Thalamus as a Blackboard for Perception and Planning.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
1 author.
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Abstract
The neocortex performs a wide range of functions, including working memory, sensory perception, and motor planning. Despite this diversity in function, evidence suggests that the neocortex is made up of repeating subunits ("macrocolumns"), each of which is largely identical in circuitry. As such, the specific computations performed by these macrocolumns are of great interest to neuroscientists and AI researchers. Leading theories of this microcircuit include models of predictive coding, hierarchical temporal memory (HTM), and Adaptive Resonance Theory (ART). However, these models have not yet explained: (1) how microcircuits learn sequences input with delay (i.e., working memory); (2) how networks of columns coordinate processing on precise timescales; or (3) how top-down attention modulates sensory processing. I provide a theory of the neocortical microcircuit that extends prior models in all three ways. Additionally, this theory provides a novel working memory circuit that extends prior models to support simultaneous multi-item storage without disrupting ongoing sensory processing. I then use this theory to explain the functional origin of a diverse set of experimental findings, such as cortical oscillations.
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Registered trials
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