Evidence map›Paper›PMID 32848591›Full record

ArticleFrontiers in neuroscience2020

Type 2 Diabetes Mellitus May Exacerbate Gray Matter Atrophy in Patients With Early-Onset Mild Cognitive Impairment.

Chang Li, Zhiwei Zuo, Daihong Liu, Rui Jiang, Yang Li, Haitao Li, Xuntao Yin, Yuqi Lai, Jian Wang, Kunlin Xiong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 6 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 6 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Chang LiDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Zhiwei ZuoDepartment of Radiology, General Hospital of Western Theater Command, Chengdu, China.
Daihong LiuDepartment of Radiology, Southwest Hospital, Army Medical University, Chongqing, China.
Rui JiangDepartment of Radiology, General Hospital of Western Theater Command, Chengdu, China.
Yang LiDepartment of Radiology, Southwest Hospital, Army Medical University, Chongqing, China.
Haitao LiDepartment of Radiology, Southwest Hospital, Army Medical University, Chongqing, China.
Xuntao YinDepartment of Medical Imaging, Guizhou Provincial People's Hospital, Guizhou, China.
Yuqi LaiSchool of Foreign Languages and Cultures, Chongqing University, Chongqing, China.
Jian WangDepartment of Radiology, Southwest Hospital, Army Medical University, Chongqing, China.
Kunlin XiongDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Army Medical University · CNSouthwest Hospital · CNChongqing University · CNDaping Hospital · CNGuizhou Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe precise physiopathological association between the courses of neurodegeneration and cognitive decline in type 2 diabetes mellitus (T2DM) remains unclear. This study sought to comprehensively investigate the distribution characteristics of gray matter atrophy in middle-aged T2DM patients with newly diagnosed mild cognitive impairment (MCI).

methodsFour groups, including 28 patients with early-onset MCI, 28 patients with T2DM, 28 T2DM patients with early-onset MCI (T2DM-MCI), and 28 age-, sex-, and education-matched healthy controls underwent three-dimensional high-resolution structural magnetic resonance imaging. Cortical and subcortical gray matter volumes were calculated, and a structural covariance method was used to evaluate the morphological relationships within the default mode network (DMN).

resultsOverlapped and unique cortical/subcortical gray matter atrophy was found in patients with MCI, T2DM and T2DM-MCI in our study, and patients with T2DM-MCI showed lower volumes in several areas than patients with MCI or T2DM. Volume loss in subcortical areas (including the thalamus, putamen, and hippocampus), but not in cortical areas, was related to cognitive impairment in patients with MCI and T2DM-MCI. No associations between biochemical measurements and volumetric reductions were found. Furthermore, patients with MCI and those with T2DM-MCI showed disrupted structural connectivity within the DMN.

conclusionThese findings provide further evidence that T2DM may exacerbate atrophy of specific gray matter regions, which may be primarily associated with MCI. Impairments in gray matter volume related to T2DM or MCI are independent of cardiovascular risk factors, and subcortical atrophy may play a more pivotal role in cognitive impairment than cortical alterations in patients with MCI and T2DM-MCI. The enhanced structural connectivity within the DMN in patients with T2DM-MCI may suggest a compensatory mechanism for the chronic neurodegeneration.

Indexed as

atrophygray mattermild cognitive impairmentstructural covariancetype 2 diabetes mellitus

Identifiers

PMID32848591
PMCPMC7432296
OpenAlexW3048878804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.