Evidence map›Paper›PMID 32848584›Full record

ArticleFrontiers in neuroscience2020

CHIME: CMOS-Hosted

Mihaly Kollo, Romeo Racz, Mina-Elraheb Hanna, Abdulmalik Obaid, Matthew R Angle, William Wray, Yifan Kong, Jan Müller, Andreas Hierlemann, Nicholas A Melosh and 1 more

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Fabrication and Validation of Sub-Cellular Carbon Fiber Electrodes.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mihaly KolloNeurophysiology of Behaviour Laboratory, Francis Crick Institute, London, United Kingdom.
Romeo RaczNeurophysiology of Behaviour Laboratory, Francis Crick Institute, London, United Kingdom.
Mina-Elraheb HannaDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, United States.
Abdulmalik ObaidDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, United States.
Matthew R AngleParadromics, Inc., Austin, TX, United States.
William WrayNeurophysiology of Behaviour Laboratory, Francis Crick Institute, London, United Kingdom.
Yifan KongParadromics, Inc., Austin, TX, United States.
Jan MüllerETH Zürich, Department of Biosystems Science and Engineering, Basel, Switzerland.
Andreas HierlemannETH Zürich, Department of Biosystems Science and Engineering, Basel, Switzerland.
Nicholas A MeloshDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, United States.
Andreas T SchaeferNeurophysiology of Behaviour Laboratory, Francis Crick Institute, London, United Kingdom.

Funding

Massive scale electrical neural recordings in vivo using commercial ROIC chipsU01NS094248 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KORDING, KONRAD P., SCHAEFER, ANDREAS · 2015 to 2017
$1.9M
Commercial development of microwire bundle technology for massively parallel neural recording.R43MH110287 · NIMH · PARADROMICS, INC. · PI ANGLE, MATTHEW R, MELOSH, NICHOLAS A · 2016 to 2017
$798k
Massively parallel microwire arrays for deep brain stimulationR21NS104861 · NINDS · STANFORD UNIVERSITY · PI DING, JUN · 2018 to 2019
$434k
Medical Research Council MC_UP_1202/5NIMH NIH HHS R43 MH110287NINDS NIH HHS R21 NS104861NINDS NIH HHS U01 NS094248Wellcome Trust FC001153
6 · The paper itself

Abstract

Mammalian brains consist of 10s of millions to 100s of billions of neurons operating at millisecond time scales, of which current recording techniques only capture a tiny fraction. Recording techniques capable of sampling neural activity at high spatiotemporal resolution have been difficult to scale. The most intensively studied mammalian neuronal networks, such as the neocortex, show a layered architecture, where the optimal recording technology samples densely over large areas. However, the need for application-specific designs as well as the mismatch between the three-dimensional architecture of the brain and largely two-dimensional microfabrication techniques profoundly limits both neurophysiological research and neural prosthetics. Here, we discuss a novel strategy for scalable neuronal recording by combining bundles of glass-ensheathed microwires with large-scale amplifier arrays derived from high-density CMOS

Indexed as

electrophysiologyextracellular recording and stimulationin vivoneurotechniquesscalable

Identifiers

PMID32848584
PMCPMC7432274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.